Lobular carcinoma in situ of the breast - correlation between minimally invasive biopsy and final pathology

Archives of Medical Science : AMS
Bartlomiej SzynglarewiczRafal Matkowski

Abstract

Lobular carcinoma in situ (LCIS) is regarded as a non-obligate precursor of invasive breast cancer (IBC). Hence, the optimal management of LCIS found on minimally invasive breast biopsy remains a subject of debate. The aim of this study was to evaluate the correlation of biopsy findings with postoperative histology and to identify risk factors for upstaging to IBC. Twenty-seven patients with pure LCIS diagnosed on image-guided biopsy (vacuum-assisted or core-needle) underwent subsequent surgery. Clinical, radiological and histological features were compared to the final pathology after surgical excision. Median age of patients was 56 years while median size of LCIS was 15 mm. Final examination demonstrated IBC foci in 29.6% of lesions. Upstaged patients were younger and had larger lesions but without statistical significance (p = 0.07 and p = 0.09, respectively). Palpable tumours (p = 0.0004), BIRADS 5 lesions (p = 0.0001), masses (p = 0.016) and pleomorphic LCIS (p = 0.0001) had a significantly increased rate of upstaging. Guidance of the procedure (ultrasound vs. stereotactic) was significantly associated with the upstaging risk (p = 0.016), while the importance of the biopsy technique (core-needle vs. vacuum-assisted) was no...Continue Reading

Citations

Dec 7, 2018·Breast Cancer Research and Treatment·Christoph J RagethZsuzsanna Varga

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