Abstract
Lobular neoplasia including lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH) may be identified in breast core needle biopsies as incidental findings or associated with microcalcifications. There are no general consensus guidelines for follow-up management in patients when lobular neoplasia is the only abnormal finding on core needle biopsy. The aim of this study was to evaluate our experience in the follow-up of these patients. A total of 3163 breast core needle biopsies were retrieved from the surgical pathology files between 2003 and 2009; among them, 56 (1.8%) cases were identified with a diagnosis of ALH or LCIS. Eleven cases were excluded because of the presence of a concurrent more severe lesion in the biopsies that mandated excision. The remaining 45 cases contained only ALH or LCIS and otherwise benign breast tissue; 27 had surgical excision follow-up. In the surgical excision specimens, 5 (19%) of 27 cases showed more severe lesions or were "upgraded" (3 invasive ductal carcinomas, 1 invasive lobular carcinoma, and 1 ductal carcinoma in situ). Histologic features of the lobular neoplasia on the cores, including association with microcalcifications, pagetoid involvement of ducts, and extensive lob...Continue Reading
References
Aug 1, 1978·Cancer·C D HaagensenC Bodian
Dec 11, 1991·Human Pathology·D L PageL W Rogers
Jun 1, 1985·Cancer·D L PageM S Rados
Mar 1, 1997·Human Pathology·R NayarS G Silverberg
Aug 31, 2000·Radiology·L E PhilpottsC H Lee
May 30, 2002·Archives of Pathology & Laboratory Medicine·Sandra J Shin, Paul Peter Rosen
Feb 20, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lavinia P MiddletonAysegul A Sahin
Apr 24, 2004·Radiology·Michelle C FosterChintana Paramagul
Jul 9, 2004·Cancer·Grazia ArpinoRichard M Elledge
Oct 14, 2004·Cancer·Daniel B Kopans
Mar 16, 2005·The American Journal of Surgical Pathology·Tarik M Elsheikh, Jan F Silverman
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul J ChubaAmr Aref
Apr 1, 1995·Clinical Molecular Pathology·S R LakhaniM R Stratton
Jan 12, 2007·The Breast Journal·Lisa E EssermanRobert Poppiti
Jul 31, 2007·The Journal of Surgical Research·Krista BowmanTara M Breslin
Mar 19, 2008·Cancer·Chandandeep S NagiShabnam M Jaffer
Apr 5, 2008·Virchows Archiv : an International Journal of Pathology·S MenonA H S Lee
May 29, 2008·Annals of Surgical Oncology·Robin M CioccaMonica Morrow
Jun 4, 2008·Archives of Pathology & Laboratory Medicine·Joan CangiarellaCecilia Mercado
Jul 16, 2008·The Breast : Official Journal of the European Society of Mastology·Viviana LonderoMassimo Bazzocchi
Citations
Jan 12, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shweta ChaudharyTawfiqul Bhuiya
Jul 3, 2013·Archives of Pathology & Laboratory Medicine·Timothy M D'AlfonsoSandra J Shin
Aug 1, 2013·Radiology·Kristen A AtkinsSandra Rao
Feb 13, 2014·The Breast : Official Journal of the European Society of Mastology·Vanessa L ProwlerM Catherine Lee
Oct 27, 2009·Journal de gynécologie, obstétrique et biologie de la reproduction·V LavouéJ Levêque
Sep 25, 2010·American Journal of Surgery·Monisha SudarshanSarkis Meterissian
Sep 22, 2009·Gynécologie, obstétrique & fertilité·A BricouE Barranger
Oct 22, 2016·AJR. American Journal of Roentgenology·Lauren Q Chang SenJules H Sumkin
Aug 20, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kelly L MooneySophia K Apple
Apr 13, 2004·Seminars in Diagnostic Pathology·Selim M Nasser
Mar 17, 2012·Indian Journal of Dermatology, Venereology and Leprology·Fiona F SequeiraIshwar Bhat
Jul 6, 2014·CytoJournal·Nora K FrischVinod B Shidham
Aug 3, 2017·Annals of Surgical Oncology·Jennifer M RaczAmy C Degnim
Dec 22, 2017·Oncotarget·Pu ChengJian Huang
Aug 31, 2020·Journal of the American College of Radiology : JACR·Mariam N ShehataKathryn P Lowry
Apr 15, 2021·AJR. American Journal of Roentgenology·Jean KunjummenMichael A Cohen