Lobular homology in cerebellar hemispheres of humans, non-human primates and rodents: a structural, axonal tracing and molecular expression analysis

Brain Structure & Function
Yuanjun LuoIzumi Sugihara

Abstract

Comparative neuroanatomy provides insights into the evolutionary functional adaptation of specific mammalian cerebellar lobules, in which the lobulation pattern and functional localization are conserved. However, accurate identification of homologous lobules among mammalian species is challenging. In this review, we discuss the inter-species homology of crus I and II lobules which occupy a large volume in the posterior cerebellar hemisphere, particularly in humans. Both crus I/II in humans are homologous to crus I/II in non-human primates, according to Paxinos and colleagues; however, this area has been defined as crus I alone in non-human primates, according to Larsell and Brodal. Our neuroanatomical analyses in humans, macaques, marmosets, rats, and mice demonstrate that both crus I/II in humans are homologous to crus I/II or crus I alone in non-human primates, depending on previous definitions, and to crus I alone in rodents. Here, we refer to the region homologous to human crus I/II lobules as "ansiform area (AA)" across animals. Our results show that the AA's olivocerebellar climbing fiber and Purkinje cell projections as well as aldolase C gene expression patterns are both distinct and conserved in marmosets and rodents. ...Continue Reading

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Citations

Aug 14, 2018·ELife·Ben DeverettSamuel S-H Wang
Aug 30, 2018·The Journal of Comparative Neurology·Rong-Jun NiJiang-Ning Zhou
Feb 10, 2019·The Journal of Comparative Neurology·Mohammad Shahangir BiswasIzumi Sugihara
Apr 17, 2020·ELife·Joshua Henk BalstersRogier B Mars
Jul 18, 2019·Nature Communications·Ben DeverettSamuel S-H Wang
Aug 28, 2020·Frontiers in Cellular Neuroscience·Timothy M LockeErik S Carlson
Nov 19, 2020·Nature Reviews. Neuroscience·Chris I De Zeeuw

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