Lobular neoplasia on core-needle biopsy--clinical significance

Cancer
Grazia ArpinoRichard M Elledge

Abstract

Approximately 25% of all cases of atypical ductal hyperplasia (ADH) diagnosed on core biopsy of the breast are associated with ductal carcinoma in situ (DCIS) or invasive malignancy at the same site. As a result, surgical excision has become the standard of care for patients with ADH. In contrast, because data on the relation between breast malignancy and lobular neoplasia (LN) detected on core biopsy are limited, clinical management of patients with LN remains controversial. The goal of the current study was to determine the incidence of breast carcinoma at sites of core biopsy exhibiting LN compared with sites of core biopsy exhibiting ADH. The results of 2053 core biopsies were reviewed to identify cases of LN and cases of ADH. Follow-up findings on excisional biopsy were categorized as malignancy (DCIS or invasive malignancy) or no malignancy and were compared between the LN group and the ADH group. Mammograms and medical records were reviewed for patients with atypical findings on core biopsy. One hundred six (5.2%) of 2053 biopsy samples exhibited atypia on core biopsy. Among these 106 samples, ADH was found in 49 (46%), LN was found in 45 (42%), and both ADH and LN were found in 12 (12%). Malignant disease was detected o...Continue Reading

References

Sep 1, 1978·The American Journal of Surgical Pathology·P P RosenD W Braun
Sep 1, 1990·Radiology·S H ParkerB J Burke
Jan 17, 1985·The New England Journal of Medicine·W D Dupont, D L Page
Sep 1, 1974·Cancer·J E WheelerJ Kirshenbaum
Mar 1, 1994·Annals of Surgical Oncology·W CarsonS B Edge
May 1, 1993·Radiology·S H ParkerD G Clark
Oct 6, 1997·Radiographics : a Review Publication of the Radiological Society of North America, Inc·S H Parker, A J Klaus
Sep 2, 1998·AJR. American Journal of Roentgenology·H E ReynoldsC L Lazaridis
Mar 6, 1999·Breast Cancer Research and Treatment·D L PageJ F Simpson
Aug 3, 1999·AJR. American Journal of Roentgenology·L LibermanD D Dershaw
Mar 15, 2001·Clinical Radiology·D O'DriscollR Warren
Apr 20, 2001·AJR. American Journal of Roentgenology·D Georgian-Smith, T J Lawton
May 30, 2002·Archives of Pathology & Laboratory Medicine·Sandra J Shin, Paul Peter Rosen
Jan 18, 2003·Lancet·Sunil R Lakhani
Feb 1, 2003·The Breast Journal·Valerie P BauerSuzanne Smith
Feb 1, 2003·The Breast Journal·Karen DmytraszAlison Estabrook
Feb 20, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lavinia P MiddletonAysegul A Sahin
Feb 27, 2003·The American Journal of Surgical Pathology·Giovanna Maria CrisiAndrew Ricci

❮ Previous
Next ❯

Citations

Mar 17, 2005·World Journal of Surgery·Walter P WeberWalter R Marti
Aug 10, 2006·Der Pathologe·H P SinnS Aulmann
Apr 5, 2008·Virchows Archiv : an International Journal of Pathology·S MenonA H S Lee
Jul 29, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Helena HwangBarbara Susnik
May 14, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Frances P O'Malley
Jan 12, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shweta ChaudharyTawfiqul Bhuiya
Feb 16, 2005·Current Opinion in Obstetrics & Gynecology·Veronique Cocquyt, Simon Van Belle
Apr 27, 2007·The American Journal of Surgical Pathology·Rouzan G KarabakhtsianDavid J Dabbs
May 1, 2010·The American Journal of Surgical Pathology·Andrea Proctor SubhawongHind Nassar
Aug 1, 2012·Annals of Surgical Oncology·Jana L LewisPaul I Tartter
Feb 22, 2008·AJR. American Journal of Roentgenology·Rachel F BremShane Wasden
Sep 22, 2012·AJR. American Journal of Roentgenology·Bethany NiellElizabeth Rafferty
Nov 16, 2005·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shin UsamiNoriaki Ohuchi
Oct 1, 2014·Archives of Pathology & Laboratory Medicine·Julie JornsJudy C Pang
Jul 31, 2007·The Journal of Surgical Research·Krista BowmanTara M Breslin
Jan 12, 2007·The Breast Journal·Lisa E EssermanRobert Poppiti
Aug 13, 2010·The Breast Journal·Ramachandran Venkitaraman
Jul 17, 2007·The Breast : Official Journal of the European Society of Mastology·Vincent LavouéJean Levêque
Aug 30, 2005·Journal of the American College of Surgeons·Kelly M McMasters
Jul 16, 2008·The Breast : Official Journal of the European Society of Mastology·Viviana LonderoMassimo Bazzocchi
Sep 22, 2009·Gynécologie, obstétrique & fertilité·A BricouE Barranger
Aug 20, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kelly L MooneySophia K Apple
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul J ChubaAmr Aref
Dec 12, 2019·AJR. American Journal of Roentgenology·Alana A Lewin, Cecilia L Mercado
Oct 5, 2007·Cancer Control : Journal of the Moffitt Cancer Center·John V KilukSusan J Hoover
Mar 19, 2008·Cancer·Chandandeep S NagiShabnam M Jaffer
Mar 25, 2018·Current Oncology Reports·Faina Nakhlis
Aug 31, 2020·Journal of the American College of Radiology : JACR·Mariam N ShehataKathryn P Lowry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Lobular

Lobular carcinoma is an invasive type of breast cancer in which lobules, areas of the breast that produce milk, undergo malignant transformation. Here is the latest research.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.