Local adipocyte cancer cell paracrine loop: can "sick fat" be more detrimental?

Hormone Molecular Biology and Clinical Investigation
Marie-Christine RioCatherine Tomasetto

Abstract

This review article focuses on the emerging role of tumor resident adipocytes. It provides in vitro and in vivo evidence that they are essential for cancer development/progression. In addition to systemic effects, their tumor-promoting impact is dependent on local functions, notably via a complex adipocyte cancer cell paracrine loop (ACCPL). Indeed, this event leads to dramatic phenotypic and/or functional modifications of both cell types as well as of the extracellular matrix. Adipocytes undergo delipidation leading to adipocytes/cancer-associated adipocytes/cancer-associated fibroblasts de-differentiation processes. In turn, cancer cell aggressiveness is exacerbated through increased proliferation, migration, and invasion properties. This is accompanied by intense tissue remodeling, conducting to the occurrence of the tumor stroma. The molecular pathways involved in ACCPL remain largely unknown. Nevertheless, several clues are starting to emerge. Moreover, obesity is currently a sign of increased risk and poor prognosis in human carcinomas. How adiposopathy might impact tumors and specifically the ACCPL is still under investigation. However, available experimental, epidemiological, and clinical data allow to draw some directi...Continue Reading

References

May 28, 1992·International Journal of Cancer. Journal International Du Cancer·B E ElliottZ Q Chen
Apr 27, 2001·Seminars in Cancer Biology·T D Tlsty
Nov 13, 2001·Developmental Cell·L Hennighausen, G W Robinson
Dec 18, 2001·Experimental Biology and Medicine·F M Gregoire
May 10, 2002·The American Journal of Pathology·Jennifer LillaZena Werb
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Chang Shu Wang, Bernard Têtu
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Mar 23, 2004·Journal of Animal Science·G J Hausman, R L Richardson
Jul 13, 2004·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D P RoseG D Stephenson
Aug 24, 2004·Oncogene·Eugenia E Calle, Michael J Thun
Nov 2, 2004·Nature Reviews. Cancer·Margareta M Mueller, Norbert E Fusenig
Apr 27, 2005·Seminars in Reproductive Medicine·William T Creasman
Jun 9, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alecia MalinWei Zheng
Oct 6, 2005·International Journal of Cancer. Journal International Du Cancer·Yasuo MiyoshiShinzaburo Noguchi
Apr 20, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Michael N VanSaun, Lynn M Matrisian
Oct 19, 2006·Trends in Immunology·Ulrike Fiedler, Hellmut G Augustin
Mar 23, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Andreas SchäfflerChrista Buechler
May 12, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Giacomo PuppaGiuseppe Pelosi
Jun 27, 2007·The American Journal of Surgical Pathology·Robert Houston ThompsonJohn C Cheville
Jul 20, 2007·Endocrine-related Cancer·Linda Vona-Davis, David P Rose
Aug 24, 2007·The New England Journal of Medicine·Lars SjöströmUNKNOWN Swedish Obese Subjects Study
Sep 21, 2007·Nature Reviews. Cancer·Javier A Menendez, Ruth Lupu
Oct 17, 2007·Breast Cancer Research and Treatment·Bilal MajedBernard Asselain
Feb 14, 2008·Diabetes, Obesity & Metabolism·Vivienne A EzzatMark T Kearney
Feb 23, 2008·Diabetes Research and Clinical Practice·Ana Bertha Zavalza-GómezJosé Miguel Mora-Martínez

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
biopsies

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Related Papers

The International Journal of Developmental Biology
Jinxiang TanMarie-Christine Rio
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yali HanYuping Sun
Journal of Leukocyte Biology
Takayoshi Suganami, Yoshihiro Ogawa
© 2021 Meta ULC. All rights reserved