PMID: 2109839Feb 1, 1990Paper

Local administration of flurazepam has different effects on dopamine release in striatum and nucleus accumbens: a microdialysis study

Neuropharmacology
T Zetterström, M Fillenz

Abstract

The action of local administration of flurazepam on extracellular levels of dopamine (DA) and its metabolites 3,4 dihydroxyphenyl acetic acid (DOPAC) and homovanillic acid (HVA) in the anterior striatum and medial nucleus accumbens have been investigated using microdialysis. Flurazepam (10 microM), administered through the perfusion medium for 20 min, reduced levels of DA in dialysates from the nucleus accumbens by 60% while the same concentration of the drug had no effect on levels of DA in perfusates from the striatum. Pretreatment with the benzodiazepine antagonist Ro 15-1788 (flumazenil) or with picrotoxin, a drug which blocks the GABAA receptor-associated chloride channel, inhibited the effect of flurazepam on levels of DA in the nucleus accumbens, which suggests that the effect was mediated by the multimolecular GABAA/benzodiazepine receptor complex. Administration of flurazepam had little effect on the two metabolites of DA, DOPAC and HVA, in either the nucleus accumbens or striatum. The inverse partial benzodiazepine agonist, FG 7142, had no significant action on the release of DA in the nucleus accumbens. These results suggest that the dopaminergic projection to the nucleus accumbens is more sensitive to benzodiazepine...Continue Reading

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Citations

Nov 9, 1993·European Journal of Pharmacology·O BlomqvistB Söderpalm
Jul 14, 1995·European Journal of Pharmacology·T SuzukiM Misawa
Oct 31, 1998·European Journal of Pharmacology·J Garcia de Mateos-VerchereJ Costentin
Jul 25, 1998·Pharmacology, Biochemistry, and Behavior·T MuraiA R Cools
Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·E MeririnneT Seppälä
Feb 28, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D Bentué-FerrerM Bourin
Jan 18, 2005·Alcoholism, Clinical and Experimental Research·Anna Molander, Bo Söderpalm
Feb 26, 2008·Pharmacology, Biochemistry, and Behavior·Stephanie C Licata, James K Rowlett
Dec 5, 2006·European Journal of Pharmacology·Elin LöfBo Söderpalm
Dec 12, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S H Woo, H S Kim
Jul 3, 2004·Journal of Clinical Psychopharmacology·Craig R RushPaul E A Glaser
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S Kasparov, A G Teschemacher
Oct 22, 2017·The Journal of Pharmacology and Experimental Therapeutics·Scott A SchelpErik B Oleson
Sep 27, 2018·ACS Chemical Neuroscience·Zachary D BrodnikRodrigo A España

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