Local administration of icariin contributes to peripheral nerve regeneration and functional recovery

Neural Regeneration Research
Bo ChenBao-Guo Jiang

Abstract

Our previous study showed that systemic administration of the traditional Chinese medicine Epimedium extract promotes peripheral nerve regeneration. Here, we sought to explore the therapeutic effects of local administration of icariin, a major component of Epimedium extract, on peripheral nerve regeneration. A poly(lactic-co-glycolic acid) biological conduit sleeve was used to bridge a 5 mm right sciatic nerve defect in rats, and physiological saline, nerve growth factor, icariin suspension, or nerve growth factor-releasing microsphere suspension was injected into the defect. Twelve weeks later, sciatic nerve conduction velocity and the number of myelinated fibers were notably greater in the rats treated with icariin suspension or nerve growth factor-releasing microspheres than those that had received nerve growth factor or physiological saline. The effects of icariin suspension were similar to those of nerve growth factor-releasing microspheres. These data suggest that icariin acts as a nerve growth factor-releasing agent, and indicate that local application of icariin after spinal injury can promote peripheral nerve regeneration.

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Citations

Sep 20, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Bo DengDandan Ke
Apr 7, 2017·Phytotherapy Research : PTR·Jae-Heung ChoYoungmin Bu
Jan 31, 2018·BMC Complementary and Alternative Medicine·Xiaolong FuJingshan Shi
May 16, 2019·Stem Cells International·Aofei YangChengjian He

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