Local administration of prostaglandin E2 for cervical ripening and labor induction: the appropriate route and dose

Acta Obstetricia Et Gynecologica Scandinavica
M Nuutila, P Kajanoja

Abstract

Although there are many comparative studies concerning the local administration of prostaglandin E2 gel for cervical ripening and labor induction, the safety, efficacy and the appropriate route and dose of the gel are still debated. One hundred and ten women with high-risk pregnancy and unripe cervix received prostaglandin E2 gel 1 mg intravaginally (n=35), 2 mg intravaginally (n=36) and 0.5 mg intracervically (n=39), maximally three times at 6-hour intervals for cervical ripening prior to labor induction. The safety, efficacy and optimal dose were assessed. The 2 mg intravaginal gel and the 0.5 mg intracervical gel were equally effective and more effective than the 1 mg intravaginal gel in labor characteristics such as ripening time and cesarean section rate, but not in labor time. However, the failure rate (labor could not be induced) was highest in the intracervical group (10.3%) compared to the intravaginal groups (2.9% and 2.8%), although the differences were not statistically significant. In the two intravaginal groups three and five patients received the third gel application and one patient in both groups could not be induced. In the intracervical group the ripening of the cervix failed in all patients, who received the...Continue Reading

Citations

Dec 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Frank Hertelendy, Tamás Zakár
Oct 31, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·F CorradoN C Stella
Mar 10, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·S LyrenäsU Ulmsten
Sep 24, 2004·Journal of Women's Health·Mary Justin-TemuGuy Van Den Mooter
Oct 30, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·H Al BarM Mushait
Apr 4, 2006·American Journal of Obstetrics and Gynecology·Filomena P NunesManuel Meirinho
Jun 6, 2002·Acta Obstetricia Et Gynecologica Scandinavica·Torsten FrambachJohannes Dietl
Feb 7, 2008·The Cochrane Database of Systematic Reviews·M BoulvainO Irion
Jun 20, 2014·The Cochrane Database of Systematic Reviews·Jane ThomasAnthony J Kelly

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