PMID: 11018768Oct 6, 2000

Local and cortical effects of olfactory bulb lesions on trophic support and cholinergic function and their modulation by estrogen

Journal of Neurobiology
F SohrabjiO A Marroquin


This study determined whether olfactory bulb lesions would affect trophic support to its afferent, the horizontal limb of the diagonal band of Broca (hIDBB), and if estrogen would ameliorate the effects of neural injury in this circuit. NMDA injections into the olfactory bulb resulted in neural injury as indicated by cell loss and increased glial fibrillary acidic protein immunoreactivity. Olfactory bulb lesions severely reduced BDNF expression in its afferent, the hIDBB, while NGF was only reduced in lesioned animals deprived of estrogen. In the olfactory bulb itself, lesions increased BDNF expression, but not NGF. Paradoxically, bulb lesions up-regulated both NGF and BDNF in another target of the hIDBB, the cingulate cortex. Moreover, olfactory bulb lesions affected choline uptake and ChAT activity locally, as well as in the cingulate cortex. Estrogen significantly attenuated the lesion-induced loss of choline uptake in the cingulate cortex, but not at the primary lesion site. Collectively, these results indicate that neural injury to one limb of the forebrain cholinergic system may result in collateral damage to other limbs of this system, suggesting a mechanism for the progression of neurodegenerative diseases, such as Alzh...Continue Reading


Jul 3, 2002·Experimental Neurology·Devin S GaryMark P Mattson
Oct 26, 2005·Neurobiology of Aging·Adam B Johnson, F Sohrabji
Jan 9, 2001·Brain Research. Molecular Brain Research·Melinda K Jezierski, F Sohrabji
Dec 14, 2002·Brain Research. Molecular Brain Research·Dean E DluzenKyungjin Kim
Dec 7, 2007·Journal of the Neurological Sciences·Chan-Il ChoiHaeyoung Suh-Kim
Sep 5, 2009·Brain Research·Yusuke Kuwagata, Hiroko Inoue


May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C D Toran-AllerandN J MacLusky
Jul 1, 1992·Neurobiology of Aging·R G Struble, H B Clark
Jan 1, 1991·Annals of the New York Academy of Sciences·R L Doty
Mar 1, 1990·The Journal of Comparative Neurology·R P GaykemaJ Traber
Mar 1, 1988·The Journal of Comparative Neurology·F H GageS Varon
Jan 1, 1986·British Medical Bulletin·E K Perry
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·F SohrabjiC D Toran-Allerand
Aug 1, 1994·Journal of Neurobiology·F SohrabjiC D Toran-Allerand
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson

Related Concepts

Cholinergic Fibers
Myoclonic Epilepsies, Progressive
Glial Fibrillary Acidic Protein
Structure of Olfactory Bulb
Recombinant Brain-Derived Growth Factors

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.