PMID: 11018768Oct 6, 2000

Local and cortical effects of olfactory bulb lesions on trophic support and cholinergic function and their modulation by estrogen

Journal of Neurobiology
F SohrabjiO A Marroquin

Abstract

This study determined whether olfactory bulb lesions would affect trophic support to its afferent, the horizontal limb of the diagonal band of Broca (hIDBB), and if estrogen would ameliorate the effects of neural injury in this circuit. NMDA injections into the olfactory bulb resulted in neural injury as indicated by cell loss and increased glial fibrillary acidic protein immunoreactivity. Olfactory bulb lesions severely reduced BDNF expression in its afferent, the hIDBB, while NGF was only reduced in lesioned animals deprived of estrogen. In the olfactory bulb itself, lesions increased BDNF expression, but not NGF. Paradoxically, bulb lesions up-regulated both NGF and BDNF in another target of the hIDBB, the cingulate cortex. Moreover, olfactory bulb lesions affected choline uptake and ChAT activity locally, as well as in the cingulate cortex. Estrogen significantly attenuated the lesion-induced loss of choline uptake in the cingulate cortex, but not at the primary lesion site. Collectively, these results indicate that neural injury to one limb of the forebrain cholinergic system may result in collateral damage to other limbs of this system, suggesting a mechanism for the progression of neurodegenerative diseases, such as Alzh...Continue Reading

References

Jul 3, 2002·Experimental Neurology·Devin S GaryMark P Mattson
Oct 26, 2005·Neurobiology of Aging·Adam B Johnson, F Sohrabji
Jan 9, 2001·Brain Research. Molecular Brain Research·Melinda K Jezierski, F Sohrabji
Dec 14, 2002·Brain Research. Molecular Brain Research·Dean E DluzenKyungjin Kim
Dec 7, 2007·Journal of the Neurological Sciences·Chan-Il ChoiHaeyoung Suh-Kim
Sep 5, 2009·Brain Research·Yusuke Kuwagata, Hiroko Inoue

Citations

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C D Toran-AllerandN J MacLusky
Jul 1, 1992·Neurobiology of Aging·R G Struble, H B Clark
Jan 1, 1991·Annals of the New York Academy of Sciences·R L Doty
Mar 1, 1990·The Journal of Comparative Neurology·R P GaykemaJ Traber
Mar 1, 1988·The Journal of Comparative Neurology·F H GageS Varon
Jan 1, 1986·British Medical Bulletin·E K Perry
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·F SohrabjiC D Toran-Allerand
Aug 1, 1994·Journal of Neurobiology·F SohrabjiC D Toran-Allerand
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson

Related Concepts

Cholinergic Fibers
Choline
Myoclonic Epilepsies, Progressive
Immunoreactivity
Glial Fibrillary Acidic Protein
Structure of Olfactory Bulb
Bulla
Neurons
Recombinant Brain-Derived Growth Factors
Uptake

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