Local and remote functional connectivity of neocortex under the inhibition influence

NeuroImage
Andrew A FingelkurtsSeppo Kähkönen

Abstract

The current paper focuses on a relatively new and promising area of the study of EEG transformations during brain information processing based on the reduction of the signal to the discrete quasi-stationary segment sequences which may reflect individual brain microstates or discrete operations. In this framework, the complex brain functions require integration of several operations throughout the whole neocortex. However, the role of inhibitory brain systems in such processes is still unsettled. The effects of a single dose (30 microg/kg) of lorazepam on the operational activity of neuronal populations and on the temporal binding between them were examined in a double-blind randomized crossover placebo-controlled study with eight healthy volunteers. EEG measures at 20 channels were evaluated on two occasions: (1) eyes closed, (2) eyes open. In short, we conducted a two-by-two factorial study where one factor manipulated GABAergic neurotransmission (lorazepam vs. placebo), and the other factor was simply brain state (eyes closed vs. eyes opened). We were primarily interested in the main effect of lorazepam. In the present study, a connection between the mesoscopic level, described by the local functional processes (neuronal asse...Continue Reading

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Citations

Jul 16, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Li-Yu HuangTzyy-Ping Jung
Aug 4, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Zeidy Muñoz-TorresMaría Corsi-Cabrera
Nov 20, 2009·The International Journal of Neuroscience·Andrew A FingelkurtsSeppo Kähkönen
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Jul 27, 2010·Neuroscience Research·Alexander A Fingelkurts, Andrew A Fingelkurts
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Jan 12, 2005·Neuroscience and Biobehavioral Reviews·Andrew A FingelkurtsSeppo Kähkönen
Feb 8, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andrew A FingelkurtsSeppo Kähkönen
Aug 8, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alexander A FingelkurtsSeppo Kähkönen
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Dec 22, 2010·Brain and Cognition·Andrew A Fingelkurts, Alexander A Fingelkurts
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Jun 17, 2006·Human Brain Mapping·Andrew A FingelkurtsSeppo Kähkönen
Mar 2, 2021·Frontiers in Computational Neuroscience·Kristine HeineyIoanna Sandvig

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