Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model.

Scientific Reports
Bernd WegenerPeter Quadbeck

Abstract

Despite the high potential of healthy bone to regenerate, the reconstruction of large bone defects remains a challenge. Due to the lack of mechanical stability of existing bone substitutes, recently developed degradable metallic alloys are an interesting alternative providing higher load-bearing capabilities. Degradable iron-based alloys therefore might be an attractive innovation. To test the suitability of a newly-designed iron-based alloy for such applications, an animal experiment was performed. Porous iron-based degradable implants with two different densities and a control group were tested. The implants were positioned in the proximal tibia of Merino sheep. Over a period of 6 and 12 months, blood and histological parameters were monitored for signs of inflammation and degradation. In the histological evaluation of the implants` environment we found degraded alloy particles, but no inflammatory reaction. Iron particles were also found within the popliteal lymph nodes on both sides. The serum blood levels of phosphorus, iron and ferritin in the long term groups were elevated. Other parameters did not show any changes. Iron-based degradable porous bone replacement implants showed a good biocompatibility in this experiment. ...Continue Reading

References

Feb 1, 1990·The Biochemical Journal·P C HeinrichT Andus
Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
Dec 10, 1991·Clinical Materials·L E Claes
Apr 22, 2004·Veterinary Research·Henrik Hagbard PetersenPeter Mikael Helweg Heegaard
May 26, 2004·The Veterinary Journal·H MurataM Yoshioka
May 17, 2005·The Veterinary Record·P DubreuilD Bélanger
Aug 27, 2005·Biomaterials·Frank WitteHenning Windhagen
Sep 29, 2005·Injury·Peter V GiannoudisEleftherios Tsiridis
Oct 6, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Peter ZartnerMichael Weyand
Nov 29, 2005·Biomaterials·Peter P MuellerMatthias Peuster
Mar 24, 2006·Cardiology in the Young·Matthias PeusterHansjoerg Hauser
Jun 13, 2006·Biomaterials·Matthias PeusterChristian von Schnakenburg
Mar 29, 2007·Journal of Biomedical Materials Research. Part a·F WitteE Willbold
Mar 29, 2007·Journal of Biomedical Materials Research. Part a·F WitteE Willbold
Jul 9, 2008·Schweizer Archiv für Tierheilkunde·A C TschuorH Lutz
Oct 7, 2008·Blood Reviews·Mary Ann KnovichFrank M Torti
Aug 6, 2009·Acta Biomaterialia·Michael SchinhammerPeter J Uggowitzer
Oct 10, 2009·Acta Biomaterialia·H HermawanD Mantovani
Apr 17, 2010·Journal of Materials Science. Materials in Medicine·Erlin ZhangFeng Shen
Jul 14, 2010·The Veterinary Journal·P D Eckersall, R Bell
Mar 29, 2011·Veterinary Immunology and Immunopathology·Peres R BadialAlexandre S Borges
Nov 28, 2012·Journal of Materials Science. Materials in Medicine·Qimao FengKun Sun
Nov 12, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mokhamad F UlumHendra Hermawan
Dec 16, 2017·ACS Applied Materials & Interfaces·Yongli QiJiandong Ding
Feb 2, 2019·The Journal of Hand Surgery·David C LobbA Bobby Chhabra
Mar 28, 2019·Biomaterials Research·Hoon-Sang Sohn, Jong-Keon Oh
Jun 6, 2020·Scientific Reports·Bernd WegenerPeter Quadbeck
Jul 15, 2020·PLoS Biology·Nathalie Percie du SertHanno Würbel
Aug 1, 2020·Injury·Rosa S ValtanenDavid W Lowenberg

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.