PMID: 11342150May 9, 2001Paper

Local anesthetic-induced microscopic and mesoscopic effects in micelles. A fluorescence, spin label and SAXS study. Single angle X-ray scattering

Biochimica Et Biophysica Acta
C V TeixeiraS Schreier

Abstract

The interaction of the local anesthetic tetracaine (TTC) with anionic sodium lauryl sulfate (SLS) and zwitterionic 3-(N-hexadecyl-N,N-dimethylammonio)propanesulfonate (HPS) micelles was investigated by fluorescence, spin labeling EPR and small angle X-ray scattering (SAXS). Fluorescence pH titrations allowed the choice of adequate pHs for the EPR and SAXS experiments, where either charged or uncharged TTC would be present. The data also indicated that the anesthetic is located in a less polar environment than its charged counterpart in both micellar systems. EPR spectra evidenced that both anesthetic forms increased molecular organization within the SLS micelle, the cationic form exerting a more pronounced effect. The SAXS data showed that protonated TTC causes an increase in the SLS polar shell thickness, hydration number, and aggregation number, whereas the micellar features are not altered upon incorporation of the uncharged drug. The combined results suggest that the electrostatic interaction between charged TTC and SLS, and the intercalation of the drug in the micellar polar region induce a change in molecular packing with a decrease in the mean cross-sectional area, not observed when the neutral drug sinks more deeply int...Continue Reading

References

Feb 1, 1976·Chemistry and Physics of Lipids·J R ErnadesH Chaimovich
Apr 1, 1977·Chemistry and Physics of Lipids·J R ErnandesS Schreier
Dec 15, 1978·Biochimica Et Biophysica Acta·S SchreierI C Smith
Apr 19, 1979·Biochimica Et Biophysica Acta·P R Cullis, A J Verkleij
Aug 12, 1976·Nature·A G Lee
Sep 21, 1976·Biochimica Et Biophysica Acta·A G Lee
Apr 15, 1988·Biochemical and Biophysical Research Communications·M L BianconiS Schreier
Nov 1, 1974·Anesthesia and Analgesia·H J AdamsG Kilpatrick
Jan 1, 1970·Progress in Biophysics and Molecular Biology·B Hille
Jun 10, 1983·Biochimica Et Biophysica Acta·J García-Soto, M S Fernández
Aug 6, 1981·Biochimica Et Biophysica Acta·M S Fernández
May 1, 1994·The British Journal of Ophthalmology·M BoljkaJ Vidensek

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Citations

Sep 29, 2004·Biophysical Chemistry·Anna Wisniewska, Agnieszka Wolnicka-Glubisz
May 19, 2007·Pharmaceutical Development and Technology·Carlota O Rangel-YaguiRosangela Itri
Nov 18, 2005·Journal of Colloid and Interface Science·Wilker CaetanoRosangela Itri
Apr 11, 2003·Journal of Colloid and Interface Science·Wilker CaetanoMarcel Tabak

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