Local anesthetic injections with or without steroid for chronic non-cancer pain: a protocol for a systematic review and meta-analysis of randomized controlled trials

Systematic Reviews
Harsha ShanthannaPrathiba Harsha

Abstract

Steroids are often combined with local anesthetic (LA) and injected to reduce pain associated with various chronic non-cancer pain (CNCP) complaints. The biological rationale behind injection of a steroid solution is unclear, and it is uncertain whether the addition of steroids offers any additional benefits over injection of LA alone. We propose to conduct a systematic review and meta-analysis to summarize the evidence for using steroids and LA vs. LA alone in the treatment of CNCP. An experienced librarian will perform a comprehensive search of EMBASE, MEDLINE, and the Cochrane Central Registry of Controlled Trials (CENTRAL) databases with search terms for clinical indications, LA, and steroid agents. We will review bibliographies of all relevant published reviews in the last 5 years for additional studies. Eligible trials will be published in English and randomly allocate patients with CNCP to treatment with steroid and LA injection therapy or injection with LA alone. We will use the guidelines published by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) to inform the outcomes that we collect and present. Teams of reviewers will independently and in duplicate assess trial eligibility,...Continue Reading

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Citations

Oct 13, 2016·Indian Journal of Anaesthesia·Kamath SriganeshJason W Busse
Jan 10, 2020·Der Radiologe·Martin G MackChristopher Herzog
Apr 27, 2020·Current Pain and Headache Reports·Laxmaiah ManchikantiJoshua A Hirsch
Jul 1, 2020·Current Pain and Headache Reports·Annemarie GalassoOmar Viswanath
Aug 14, 2020·Current Pain and Headache Reports·Morgan HasegawaOmar Viswanath
Feb 6, 2020·Current Pain and Headache Reports·Ivan UritsOmar Viswanath
Sep 4, 2021·Journal of the American Podiatric Medical Association·Steven R EdwardsKarl B Landorf

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

PRISMA
DistillerSR
revman
IMMPACT
Cochrane

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