Local application of angiotensin II to the rat carotid artery induces adventitial thickening

Journal of Vascular Research
K J Scheidegger, J M Wood

Abstract

The aim of this study was to determine the effects of angiotensin II (Ang II) on the vascular wall, that are independent of its effects on systemic blood pressure. Ang II has been shown to have different effects on vascular growth in vitro and in vivo. The generally weak effects of Ang II in cell culture may be due to the absence of blood-borne factors and interactions between different cell types, dedifferentiation of cells and receptor loss. On the other hand, studies with administration of Ang II in vivo are complicated by effects on blood pressure and it is not clear whether the effects of Ang II are direct or secondary. In order to overcome some of these limitations, we delivered Ang II locally to the left carotid artery of normotensive rats with a perivascular drug delivery system, in doses that did not affect systemic blood pressure. Ang II was applied perivascularly to the artery in doses of 0.05, 0.5, 5 and 50 ng/h for 14 days. A vehicle-treated group and the right carotid artery served as controls. Other groups received noradrenaline as a control for the vasoconstrictive actions of Ang II. Ang II, but not noradrenaline, induced a dose-dependent thickening of the adventitia with increased cellularity which was characte...Continue Reading

Citations

Jul 8, 1999·Regulatory Peptides·M de Gasparo, H M Siragy
Apr 8, 1999·Journal of the American College of Cardiology·H P Brunner-La RoccaM D Esler
Sep 16, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Susan E CrawfordLijun Huang
Jan 31, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas WaltherGünter Mies
Aug 26, 2003·The American Journal of Pathology·Stella SarlosJennifer L Wilkinson-Berka

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