PMID: 8945734Nov 1, 1996Paper

Local application of anti-NGF blocks the collateral sprouting in rats following chronic constriction injury of the sciatic nerve

Neuroscience Letters
L S RoH S Chang

Abstract

Systemic administration of anti-nerve growth factor (NGF) antibodies can block nociceptive fiber sprouting into denervated adult rat skin. However, the effect of local application of anti-NGF on collateral sprouting in rats caused by chronic constriction injury (CCI) has not been well studied. We investigated the influence of local anti-NGF on collateral sprouting caused by CCI of the rat's sciatic nerve. Using a dye-labeled plasma extravasation technique, we can easily evaluate the extent of collateral sprouting by the clearly defined blue coloration area. Our results showed that local application of anti-NGF either in a high or low dose significantly prevented the spread of collateral sprouting from the saphenous nerve into the sciatic innervation territory. In contrast, distilled water did not show a significant block of the saphenous nerve collateral sprouting. Our study suggests that collateral sprouting is dependent on the local availability of NGF by the nearby intact cutaneous nerve fibers.

References

May 1, 1979·The Journal of Comparative Neurology·M DevorP D Wall
Apr 1, 1993·Neuroreport·K M MearowJ Diamond

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Citations

May 29, 2007·Neurosurgical Review·Wiesław MarcolJoanna Lewin Kowalik
May 22, 2003·Progress in Neurobiology·Hitoshi YasudaRyuichi Kikkawa
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jan 28, 2005·The European Journal of Neuroscience·Orlando Guntinas-LichiusDoychin N Angelov
Feb 25, 2006·Neurologia Medico-chirurgica·Joanna Lewin-KowalikAndrzej Klimczak
Jan 30, 2013·Journal of Forensic and Legal Medicine·Charles G Davis
Jan 3, 2012·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·L S DurakuR W Selles
Feb 8, 2003·Journal of Neuroscience Methods·D S McDonald, D W Zochodne
Nov 8, 2016·Neuroscience·Wolfgang Pita-ThomasManuel Nieto-Diaz
Jul 20, 2001·British Journal of Anaesthesia·D BridgesA S Rice

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