PMID: 11336914May 5, 2001Paper

Local application of growth factors (insulin-like growth factor-1 and transforming growth factor-beta1) from a biodegradable poly(D,L-lactide) coating of osteosynthetic implants accelerates fracture healing in rats

Bone
G SchmidmaierM Raschke

Abstract

In vitro and in vivo studies have demonstrated an osteoinductive effect of growth factors such as insulin-like growth factor-1 (IGF-1) and transforming growth factor-beta1 (TGF-beta1). However, for therapeutic use in fracture treatment, questions remain with regard to the local application of these proteins. A controlled, local release of growth factors from a biodegradable polylactide coating of osteosynthetic implants may have a stimulating effect on fracture healing. Such implants could stabilize the fracture and their bioactive surface could function simultaneously as a local drug-delivery system. Previous studies have demonstrated the high mechanical stability of an approximately 10-14-microm-thick poly(D,L-lactide) (PDLLA) coating on metallic implants, which can even withstand the process of intramedullary insertion. Following an initial peak, 80% of incorporated growth factors IGF-1 and TGF-beta1 were continuously released within 42 days. The effect of locally applied IGF-1 and TGF-beta1 from a biodegradable PDLLA coating of intramedullary implants on fracture healing was investigated in a rat model. Midshaft fractures of the right tibia of 5-month-old female Sprague-Dawley rats (n = 127) were stabilized with coated vs. ...Continue Reading

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Citations

Jun 19, 2001·Journal of Biomedical Materials Research·G SchmidmaierM Raschke
Dec 2, 2009·Calcified Tissue International·Leila KoliosEwa Klara Stuermer
Aug 1, 2009·Langenbeck's Archives of Surgery·Sabrina EhnertAndreas Nussler
Apr 25, 2006·Anatomy and Embryology·Sergio MoriniEugenio Gaudio
Nov 18, 2003·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·F KandzioraN P Haas
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Oct 10, 2008·BMC Musculoskeletal Disorders·Christine KratzelBritt Wildemann
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