PMID: 9659887Jul 11, 1998Paper

Local application of recombinant active-site inhibited human clotting factor VIIa reduces thrombus weight and improves patency in a rabbit venous thrombosis model

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
J HolstU Hedner

Abstract

To study whether locally administered recombinant inactivated human coagulation factor VIIa (FFR-rFVIIa) would reduce the thrombus formation and improve patency in an experimental venous thrombosis model without inducing systemic changes in the coagulation. Experimental double-dummy randomised study. In 20 healthy New Zealand White rabbits both jugular veins were exposed under general anaesthesia. The thrombi were induced in a 10 mm long jugular vein segment with a combination of chemical destruction of the intima and a restriction of the bloodflow. Each segment was treated with either FFR-rFVIIa or placebo injected directly into the vein. 1.5 mg topically applied FFR-rFVIIa significantly reduced the thrombus weight (p < 0.001). The 30 and the 120 min patency tests were significantly improved (p < 0.05 and p < 0.001, respectively) Plasma analyses (APTT, dilute-TF time, FVII protein) were evaluated as baseline, 3 min after declamping and at sacrifice. No prolongation of the clotting times were seen. FFR-rFVIIa protein was detected in minute amounts (ng/ml); however, this was not enough to prolong the dilute-TF time. Local application of recombinant active-site inhibited human FVIIa reduced both thrombus weight and improved paten...Continue Reading

References

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Citations

Apr 26, 2003·American Journal of Respiratory and Critical Care Medicine·Martha Sue CarrawayClaude A Piantadosi
Aug 16, 2001·Journal of Clinical Pharmacology·E ErhardtsenM S Thomsen
Sep 12, 2002·Expert Opinion on Therapeutic Targets·Donald S Houston
Feb 15, 2000·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·B Povlsen, A Sirsjö
Feb 13, 2001·British Journal of Haematology·F GhribB Boneu
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·J HimberM A Riederer
Jun 13, 2000·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·L V Rao, M Ezban

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