Local cerebral blood flow in a rat cortical vein occlusion model

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Hiroyuki NakaseO Kempski

Abstract

The symptoms following sinus and vein occlusion observed in patients and experimental animals display a considerable variability that so far remains largely unexplained. In a rat cortical vein occlusion model using a photochemical thrombotic technique, we examined changes in the cerebral venous flow pattern by fluorescence angiography and regional cerebral blood flow (rCBF) and cerebral blood volume fraction (CBVF) by a modern laser Doppler "scanning" technique. Brain damage was assessed histologically. Fluorescence angiographic findings fell into two groups: group A, rats with an altered venous flow pattern after occlusion (n = 12), and group B, rats with interruption of blood flow and/or a growing venous thrombus (n = 5). In addition, sham-operated animals made up group C (n = 5). Extravasation of fluorescein, a massive decrease in rCBF, a short-lasting increase in CBVF, and regional brain damage were typical for group B. In addition, cortical CBF mapping revealed a transient hyperperfusion zone with hyperemia surrounding a hypoperfused ischemic core in group B. A circulation perturbation following venous occlusion appeared near those occluded cerebral veins without sufficient collateral flow. Furthermore, the venous thrombus...Continue Reading

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Citations

Oct 8, 2003·Critical Care Medicine·A HeimannO Kempski
Mar 21, 2002·Neurologia Medico-chirurgica·Hiroyuki NakaseToshisuke Sakaki
Nov 3, 2009·Neurosurgical Focus·J Nicole BentleyJohn R Vender
Aug 10, 2000·Journal of Neurosurgery·H OtsukaT Sakaki
Jun 17, 2006·Journal of Neurosurgery·Toshikazu NishiokaToshisuke Sakaki
Aug 28, 2012·Indian Journal of Pharmaceutical Sciences·W PathiranaR Kamaladiwela
Aug 16, 2014·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Olalekan Michael OgundeleGbolahan Wasiu Balogun
Nov 28, 2012·World Neurosurgery·Guangwen LiXunming Ji
Aug 27, 2014·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Olalekan Michael OgundeleAmin Abdulbasit
Apr 21, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Daisuke WajimaHiroyuki Nakase
Mar 19, 2015·Experimental Neurology·Sheng ChenJohn H Zhang
Nov 10, 2009·Brain Research·Daisuke WajimaHiroyuki Nakase
Mar 7, 2002·Neurological Research·Carlo SchallerToshisuke Sakaki
Jul 30, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yasuhiro TakeshimaHiroyuki Nakase
Jun 17, 2016·Drug and Chemical Toxicology·Olalekan Michael OgundeleAmin Abdulbasit
Aug 12, 2005·Neurosurgery·Ichiro NakagawaOliver Kempski
Nov 27, 2014·Biomedical Optics Express·Georgios TsiminisTanya M Monro
Oct 3, 2017·Neural Regeneration Research·Ryo TamakiAxel Heimann
Mar 7, 2021·Translational Stroke Research·Marie-Charlotte BourrienneMikaël Mazighi
May 7, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Wenbo LiQin Qin

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Methods Mentioned

BETA
Fluorescence
blood pooling

Software Mentioned

Stat
Sigma

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