Local changes in GC/AT substitution biases and in crossover frequencies on Drosophila chromosomes

Molecular Biology and Evolution
T Takano-Shimizu


I present here evidence of remarkable local changes in GC/AT substitution biases and in crossover frequencies on Drosophila chromosomes. The substitution pattern at 10 loci in the telomeric region of the X chromosome was studied for four species of the Drosophila melanogaster species subgroup. Drosophila orena and Drosophila erecta are clearly the most closely related species pair (the erecta complex) among the four species studied; however, the overall data at the 10 loci revealed a clear dichotomy in the silent substitution patterns between the AT-biased- substitution melanogaster and erecta lineages and the GC-biased-substitution yakuba and orena lineages, suggesting two or more independent changes in GC/AT substitution biases. More importantly, the results indicated a between- loci heterogeneity in GC/AT substitution bias in this small region independently in the yakuba and orena lineages. Indeed, silent substitutions in the orena lineage were significantly biased toward G and C at the consecutive yellow, lethal of scute, and asense loci, but they were significantly biased toward A and T at sta. The substitution bias toward G and C was centered in different areas in yakuba (significantly biased at EG:165H7.3, EG:171D11.2, a...Continue Reading


May 18, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·F Lemeunier, M A Ashburner
Mar 21, 1977·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D L Lindsley, L Sandler
Feb 1, 1992·Genetical Research·D CharlesworthB Charlesworth
May 1, 1989·Journal of Molecular Evolution·P M Sharp, W H Li
Jan 1, 1986·Journal of Molecular Evolution·M SolignacJ C Mounolou
Jan 1, 1986·Journal of Molecular Evolution·G Bernardi, G Bernardi
Dec 1, 1988·Journal of Molecular Evolution·G BernardiG Bernardi
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·N SUEOKA
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C W Birky, J B Walsh
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A Muto, S Osawa
May 24, 1985·Science·G BernardiF Rodier
Feb 1, 1974·Genetical Research·J M Smith, J Haigh
Dec 1, 1966·Genetical Research·W G Hill, A Robertson
Jan 1, 1995·Annual Review of Genetics·G Bernardi
Sep 1, 1997·Molecular Biology and Evolution·M Lynch
Sep 26, 1997·Journal of Molecular Evolution·D CasaneW Li
Oct 29, 1997·Journal of Molecular Evolution·E N Moriyama, J R Powell
Dec 24, 1997·Molecular Biology and Evolution·V L Bauer, C F Aquadro
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·O N DanilevskayaM L Pardue
Dec 10, 1998·Nucleic Acids Research·FlyBase Consortium
Sep 2, 1999·Current Biology : CB·G MatassiC Gautier
Apr 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·N SUEOKA
Jan 1, 1989·Evolution; International Journal of Organic Evolution·William R Rice


Dec 16, 2004·Journal of Molecular Evolution·Jennifer J Wernegreen, Daniel J Funk
Dec 13, 2006·Journal of Molecular Evolution·Elizabeth T CirulliMohamed A F Noor
Apr 26, 2007·Journal of Molecular Evolution·Doris Bachtrog
Dec 31, 2009·Journal of Molecular Evolution·Kai Zeng, B Charlesworth
Jun 13, 2003·Trends in Genetics : TIG·Gabriel Marais
Oct 30, 2001·Current Opinion in Genetics & Development·J M Comeron
Nov 16, 2002·Current Opinion in Genetics & Development·Wen-Hsiung LiKateryna Makova
Nov 20, 2012·Genome Biology and Evolution·Yu-Ping PohD J Begun
Apr 9, 2009·Molecular Biology and Evolution·Nadia D SinghC F Aquadro
Dec 19, 2002·Evolution; International Journal of Organic Evolution·Ana LlopartJerry A Coyne
Sep 15, 2005·Genetics·Nicolas GaltierN Bierne
Sep 25, 2007·Genetics·Carlos Díaz-Castillo, Kent G Golic
Apr 13, 2012·Journal of Medical Entomology·Yoosook LeeAnthony J Cornel
Jan 13, 2006·Journal of Evolutionary Biology·N Bierne, A Eyre-Walker
Oct 2, 2012·Journal of Evolutionary Biology·F Clemente, C Vogl
Feb 8, 2007·Genome Biology·Penelope R HaddrillB Charlesworth
Mar 1, 2003·Nature Genetics·Kenneth H Wolfe, Wen-Hsiung Li
Jun 13, 2006·Genome Génome / Conseil National De Recherches Canada·Jin-Feng ChenShi-Heng Tao
May 27, 2005·Molecular Biology and Evolution·David BenovoyGuy Drouin

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