PMID: 9529095Apr 7, 1998Paper

Local chemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis

Infection and Immunity
Richard P DarveauRichard J Lamont

Abstract

Periodontitis, which is widespread in the adult population, is a persistent bacterial infection associated with Porphyromonas gingivalis. Gingival epithelial cells are among the first cells encountered by both P. gingivalis and commensal oral bacteria. The chemokine interleukin 8 (IL-8), a potent chemoattractant and activator of polymorphonuclear leukocytes, was secreted by gingival epithelial cells in response to components of the normal oral flora. In contrast, P. gingivalis was found to strongly inhibit IL-8 accumulation from gingival epithelial cells. Inhibition was associated with a decrease in mRNA for IL-8. Antagonism of IL-8 accumulation did not occur in KB cells, an epithelial cell line that does not support high levels of intracellular invasion by P. gingivalis. Furthermore, a noninvasive mutant of P. gingivalis was unable to antagonize IL-8 accumulation. Invasion-dependent destruction of the gingival IL-8 chemokine gradient at sites of P. gingivalis colonization (local chemokine paralysis) will severely impair mucosal defense and represents a novel mechanism for bacterial colonization of host tissue.

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Citations

Oct 16, 1999·Periodontology 2000·S C HoltC A Genco
Feb 24, 2000·Journal of Periodontal Research·F A Scannapieco, R J Genco
Jan 12, 2002·FEMS Microbiology Letters·Periathamby Antony Raj, Andrew R Dentino
Mar 13, 2002·Annals of Periodontology·M S Terpenning
Sep 19, 2002·Periodontology 2000·Frank A Roberts, Richard P Darveau
Sep 19, 2002·Periodontology 2000·Richard J Lamont, Ozlem Yilmaz
Mar 1, 2003·Journal of Periodontal Research·Gustavo P GarletJoão S Silva
Apr 27, 2004·Periodontology 2000·Douglas R DixonRichard P Darveau
Jan 12, 2007·Periodontology 2000·Iain L C Chapple, John B Matthews
Nov 10, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Pedro de Sousa Gomes, Maria Helena Fernandes
Oct 20, 2010·Journal of Clinical Periodontology·Melissa M GrantHelen R Griffiths
Aug 18, 2010·Periodontology 2000·John J Taylor
Jun 2, 2010·Nature Reviews. Microbiology·Richard P Darveau
Feb 26, 2011·Journal of Clinical Periodontology·Moritz Kebschull, Panos N Papapanou
May 7, 2011·Molecular Oral Microbiology·B C DickinsonR J Lamont
Feb 7, 2012·Journal of Clinical Periodontology·Fumi TateishiKazuyuki Noguchi
Apr 26, 2012·FEMS Microbiology Letters·Nagihan Bostanci, Georgios N Belibasakis
Sep 4, 2012·Nature Reviews. Microbiology·George HajishengallisMichael A Curtis
Jul 10, 2012·Journal of Dental Research·R P DarveauM A Curtis
Jul 20, 2012·Expert Review of Proteomics·Masae KuboniwaMurray Hackett
May 23, 2015·Frontiers in Cellular and Infection Microbiology·Purnima S Kumar, Matthew R Mason
Aug 26, 2015·Virulence·G N BelibasakisNagihan Bostanci
Mar 18, 2016·Cellular and Molecular Life Sciences : CMLS·Sonal ShreeRavishankar Ramachandran
Apr 9, 2016·Genome Announcements·Thao T ToJeffrey S McLean
Oct 5, 2016·Scientific Reports·Kenneth Barth, Caroline Attardo Genco
May 19, 2001·Oral Microbiology and Immunology·Q D DengH K Kuramitsu

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