Local circuit connections between hamster laminae III and IV dorsal horn neurons

Journal of Neurophysiology
S P Schneider

Abstract

To better understand the role of intrinsic spinal cord circuits in the integration of mechanosensory information, we studied synaptic transmission between neurons in Rexed's laminae III-IV, a major termination zone for cutaneous mechanoreceptor afferents, using dual, simultaneous whole cell electrophysiological recordings in young hamsters. Synaptic connections were detected between 32 of 106 cell pairs (linkage probability of 0.3) and were predominantly unidirectional (91%). Inhibitory connections outnumbered excitatory connections by 2:1. Amplitude of single-axon postsynaptic potentials (PSPs) was independent of postsynaptic cell input resistance. Intracellular labeling suggested that recordings were obtained from local axon interneurons. In connected cell pairs, the percentage of presynaptic action potentials that failed to evoke a postsynaptic response was 44 +/- 29%. Shape indices of PSPs suggested that synaptic contacts were widely distributed along the postsynaptic membrane. Linkage probability was unrelated to intrinsic firing properties, laminar position of the cells or the distance (<160 mum) separating them. However, PSPs in target cells following action potentials in neurons with phasic firing patterns had longer du...Continue Reading

References

Sep 1, 1979·Journal of Neurophysiology·P B BrownR P Yezierski
Jul 15, 1976·The Journal of Comparative Neurology·H Mannen, Y Sugiura
Dec 1, 1990·Biophysical Journal·H R Lüscher, J S Shiner
Jan 1, 1989·Neuroscience·A J Todd, J McKenzie
Mar 1, 1973·Experimental Neurology·J E Heavner, R H De Jong
Jun 1, 1968·Brain Research·M E Scheibel, A B Scheibel
Jan 1, 1968·Experimental Brain Research·D R CurtisG A Johnston
May 8, 1995·The Journal of Comparative Neurology·S P SchneiderB D Johnson
Jan 1, 1995·The European Journal of Neuroscience·A J ToddM Neilson
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·C Allen, C F Stevens
Nov 1, 1995·Journal of Neurophysiology·M C JiangG F Gebhart
Feb 1, 1996·Brain Research. Molecular Brain Research·T J GrudtG Henderson
Apr 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan Lu, Edward R Perl

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Citations

Sep 13, 2012·The European Journal of Neuroscience·Hugues PetitjeanRémy Schlichter
Aug 21, 2015·Neuron·Cedric PeirsRebecca P Seal
May 22, 2010·Journal of Neuroscience Methods·Anders Sonne MunchJean-François Perrier
Oct 27, 2016·Neuroscience·Matilde Cordero-ErausquinSylvain Hugel
Oct 2, 2009·Journal of Neurophysiology·Yishen ChenPeter A Smith

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