Local circuit input to the medullary reticular formation from the rostral nucleus of the solitary tract.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
J NasseJ B Travers

Abstract

The intermediate reticular formation (IRt) subjacent to the rostral (gustatory) nucleus of the solitary tract (rNST) receives projections from the rNST and appears essential to the expression of taste-elicited ingestion and rejection responses. We used whole cell patch-clamp recording and calcium imaging to characterize responses from an identified population of prehypoglossal neurons in the IRt to electrical stimulation of the rNST in a neonatal rat pup slice preparation. The calcium imaging studies indicated that IRt neurons could be activated by rNST stimulation and that many neurons were under tonic inhibition. Whole cell patch-clamp recording revealed mono- and polysynaptic projections from the rNST to identified prehypoglossal neurons. The projection was primarily excitatory and glutamatergic; however, there were some inhibitory GABAergic projections, and many neurons received excitatory and inhibitory inputs. There was also evidence of disinhibition. Overall, bath application of GABA(A) antagonists increased the amplitude of excitatory currents, and, in several neurons, stimulation of the rNST systematically decreased inhibitory currents. We have hypothesized that the transition from licks to gapes by natural stimuli, su...Continue Reading

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Citations

May 9, 2012·Chemical Senses·Marion E FrankThomas P Hettinger
Apr 20, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zhixiong ChenJoseph B Travers
Nov 22, 2011·The Psychiatric Clinics of North America·Lucy F Faulconbridge, Matthew R Hayes
Oct 20, 2009·Frontiers in Neuroendocrinology·Harvey J Grill
Aug 14, 2009·Current Opinion in Neurobiology·Alan C Spector, John I Glendinning
Jul 30, 2011·The Journal of Comparative Neurology·James CorsonAlev Erisir
Sep 10, 2014·Journal of Neuroscience Methods·Jason S Nasse
Aug 6, 2013·Hormones and Behavior·Jill E SchneiderErin Keen-Rhinehart
May 9, 2014·Journal of Neurophysiology·Jason S Nasse, Joseph B Travers
Nov 22, 2016·Journal of Neuroscience Research·Louis J Martin, Suzanne I Sollars
Mar 29, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Richard C RogersGerlinda E Hermann
Jan 31, 2021·Nutrients·Patricia M Di Lorenzo

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