Local control and vertebral compression fractures following stereotactic body radiotherapy for spine metastases

Journal of Bone Oncology
Yurday OzdemirErkan Topkan

Abstract

We aimed to retrospectively assess the incidence of vertebral compression fractures (VCF), examine clinicopathologic factors potentially associated with VCF, and evaluate treatment response in patients who received stereotactic body radiotherapy (SBRT) for spine metastases (spMets). We identified 78 patients with 125 spMets at baseline and subsequent assessments. Patients received SBRT doses of 16 or 18 Gy. Patients with pre-existing VCF and co-existing local progression were excluded. Spine instability neoplastic score (SINS) was used for spMets categorization. Response to SBRT and VCF were assessed according to the Positron Emission tomography Response Criteria In Solid Tumors (PERCIST) and Genant scores, respectively. Kaplan-Meier analyses were used to assess local control of disease and vertebral compression fracture-free survival (FFS). We treated 103 cases with single spMets and 11 cases involving double spMets with SBRT. Progressive disease was reported in 3.2% and 8.2% of the cases in the first and last PET/CT reports, respectively. The distribution of treatment response in the remaining patients was: complete response in 30.6% of patients, partial response in 47.1% of patients, and stable disease in 22.3% of patients i...Continue Reading

Citations

Apr 28, 2020·Technology in Cancer Research & Treatment·Antonio PontorieroStefano Pergolizzi
Jun 27, 2020·Physical and Engineering Sciences in Medicine·James RijkenTanya Kairn
Mar 17, 2020·Journal of Medical Imaging and Radiation Oncology·Hussein AbbouchieFarshad Foroudi

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