Local control in advanced head and neck cancer by combined modalities of treatment

Journal of Surgical Oncology
B JoseS C Sharma


From July 1979 to January 1983, 20 patients with locally advanced head and neck cancer were treated with a combination of chemotherapy and irradiation with or without surgery. A majority of the patients were in the age range of 45 to 54 years. Eighty-five percent of the patients were male. Seventy-five percent of the patients had oral cavity lesions, the tongue being the most common site. Eighty percent of the patients had T4 lesion and 35% had N3 disease in the neck. A majority of the patients had combination chemotherapy, including bleomycin, methotrexate, and cisplatinum (BMP). All patients received irradiation with megavoltage equipment and 55% of patients received a dose of 5,000 to 6,000 rads in 5-6 weeks time. The tumor was converted to be resectable in ten patients. Nine patients (45%) had the neck and primary tumor completely controlled, while six patients (30%) had partial control. Six of the ten patients who had resection had the tumor controlled at the primary site and neck. The median duration of follow-up is 12 months (range, 4-32 months). The median survival of the whole group of patients is 12.5 months. A brief review of the current literature is also done in this paper.


Oct 1, 1980·American Journal of Surgery·M B SpauldingJ M Loré
Oct 1, 1980·American Journal of Surgery·A WeaverM Al-Sarraf
Feb 1, 1981·International Journal of Radiation Oncology, Biology, Physics·J H Glick, S G Taylor
Jul 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P C AmreinS A Weitzman

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Nov 28, 2012·European Journal of Clinical Pharmacology·Zahra Nasiri-ToosiMahboob Lessan-Pezeshki

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