PMID: 8948337Oct 1, 1996Paper

Local control in synchronous bilateral Wilms tumor

International Journal of Radiation Oncology, Biology, Physics
Arnold C PaulinoL E Kun

Abstract

To evaluate the role of radiation therapy (RT), chemotherapy (CT), and surgery in the local control of synchronous bilateral Wilms Tumor (WT). Between 1962 to 1993, 45 children were treated for bilateral WT; 38 patients with synchronous tumors were reviewed. Initial surgery depended on the era of treatment and included unilateral nephrectomy (N)/partial nephrectomy (PN) and contralateral PN in 6, unilateral N/PN alone in 7, and biopsy only in 25. Chemotherapy (CT) consisted of vincristine, actinomycin-D, and adriamycin in 32 and vincristine/ actinomycin-D in 6. Radiation therapy (RT) was given to 32 patients. Treatment included both kidneys in 20, unilateral kidney plus contralateral renal bed in 9, unilateral kidney in 2, and unilateral renal bed in 1. Follow-up was 16 months to 25 years (median: 6.3 years). Local control (LC) has been maintained in 66 out of 76 sites (87%). For Stage I-II disease with initial N/PN, LC was 10 out of 12 with RT and 11 out of 11 without RT; for Stage III with initial N/PN, LC was 8 out of 9 with RT and 1 out of 1 without RT. Initial CT and RT was followed by delayed N/PN for 20 sites; LC was 15 out of 17 in post induction Stage I-II and 1 out of 3 in postinduction Stage III. In 23 sites undergoi...Continue Reading

References

Oct 1, 1977·Journal of Pediatric Surgery·H C BishopG J D'Angio
Jun 1, 1992·The British Journal of Radiology·P Kirkbride, P N Plowman
Aug 1, 1987·Journal of Pediatric Surgery·J M LabergeD P Doody
Nov 15, 1985·Cancer·M J AschH Isaacs
Dec 1, 1986·Journal of Pediatric Surgery·O P TuckerF J Harberg
Mar 15, 1987·Cancer·Y MishrikiL Nathanson
May 1, 1983·International Journal of Radiation Oncology, Biology, Physics·P R ThomasV J Land
Jul 1, 1980·International Journal of Radiation Oncology, Biology, Physics·S S DonaldsonL F Fajardo
Aug 1, 1959·Radiology·G J D'ANGIOC L MADDOCK

❮ Previous
Next ❯

Citations

Mar 5, 2013·Pediatric Surgery International·G P HadleyP K Ramdial
Mar 22, 2000·International Journal of Radiation Oncology, Biology, Physics·A C PaulinoD H Hussey
Feb 13, 2014·Journal of Pediatric Urology·David I ChuJonathan C Routh
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Laura A DawsonTimothy E Schultheiss
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey S DomeKathy Pritchard-Jones
Jan 12, 2012·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Amal HalimOsama Sarhan
Sep 5, 2014·The Cochrane Database of Systematic Reviews·Elvira C van DalenLeontien C M Kremer
Jul 11, 2009·Expert Review of Anticancer Therapy·Peter F Ehrlich
Feb 16, 1999·Seminars in Surgical Oncology·R C Shamberger
Jul 9, 2017·Indian Journal of Pediatrics·Akash KumarSandeep Agarwala
Nov 4, 2020·International Journal of Surgery Case Reports·Irfan WahyudiArry Rodjani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.