Local Control of Aldosterone Production and Primary Aldosteronism

Trends in Endocrinology and Metabolism : TEM
Enzo LalliRichard Warth

Abstract

Primary aldosteronism (PA) is caused by excessive production of aldosterone by the adrenal cortex and is determined by a benign aldosterone-producing adenoma (APA) in a significant proportion of cases. Local mechanisms, as opposed to circulatory ones, that control aldosterone production in the adrenal cortex are particularly relevant in the physiopathological setting and in the pathogenesis of PA. A breakthrough in our understanding of the pathogenetic mechanisms in APA has been the identification of somatic mutations in genes controlling membrane potential and intracellular calcium concentrations. However, recent data show that the processes of nodule formation and aldosterone hypersecretion can be dissociated in pathological adrenals and suggest a model envisaging different molecular events for the pathogenesis of APA.

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Jul 26, 2016·Frontiers in Endocrinology·Nada El GhorayebAndré Lacroix
Sep 13, 2016·Molecular and Cellular Endocrinology·Renate Louw-du ToitDonita Africander
Nov 20, 2016·Acta Physiologica·S Bandulik
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Mar 16, 2017·Hypertension·Rene BaudrandAnand Vaidya
Jun 2, 2017·Circulation·Kazutaka NanbaWilliam E Rainey
Aug 8, 2018·The Journal of Clinical Endocrinology and Metabolism·Kang-Yung PengKwan-Dun Wu
Sep 29, 2017·Endocrinology and Metabolism·Jian Jhong WangKwan Dun Wu
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Oct 7, 2021·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Piotr Kmieć, Krzysztof Sworczak

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