Local Control of Extracellular Dopamine Levels in the Medial Nucleus Accumbens by a Glutamatergic Projection from the Infralimbic Cortex

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
César QuirozSergi Ferré

Abstract

It is generally assumed that infralimbic cortex (ILC) and prelimbic cortex, two adjacent areas of the medial prefrontal cortex (mPFC) in rodents, provide selective excitatory glutamatergic inputs to the nucleus accumbens (NAc) shell and core, respectively. It is also generally believed that mPFC influences the extracellular levels of dopamine in the NAc primarily by an excitatory collateral to the ventral tegmental area (VTA). In the present study, we first established the existence of a selective functional connection between ILC and the posteromedial portions of the VTA (pmVTA) and the mNAc shell (pmNAc shell), by measuring striatal neuronal activation (immunohistochemical analysis of ERK1/2 phosphorylation) and glutamate release (in vivo microdialysis) upon ILC electrical stimulation. A novel optogenetic-microdialysis approach allowed the measurement of extracellular concentrations of glutamate and dopamine in the pmNAc shell upon local light-induced stimulation of glutamatergic terminals from ILC. Cortical electrical and local optogenetic stimulation produced significant increases in the extracellular concentrations of glutamate and dopamine in the pmNAc shell. Local blockade of glutamate release by perfusion of an adenosin...Continue Reading

Citations

Nov 25, 2017·Annals of Neurology·Gabriel YepesSergi Ferré
Jan 24, 2018·Frontiers in Neuroscience·Sergi FerréDiego García-Borreguero
Jul 27, 2018·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Sergi FerréChristopher J Earley
Jul 14, 2018·EMBO Reports·Jean-François De BackerAlban de Kerchove d'Exaerde
Jul 20, 2018·Journal of Caffeine and Adenosine Research·David BlumPatrizia Popoli
Aug 14, 2019·Nature Biotechnology·James A FrankPolina Anikeeva
Apr 5, 2019·Journal of Caffeine and Adenosine Research·Sergi Ferré
Oct 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ferenc ZádorLászló Vécsei
Sep 29, 2019·Journal of Caffeine and Adenosine Research·Sergi Ferré, Francisco Ciruela
Feb 14, 2021·Neuroscience and Biobehavioral Reviews·Ewa Galaj, Robert Ranaldi
Apr 3, 2021·Analytical Chemistry·Marsilea A BoothMartyn G Boutelle
Jul 13, 2018·ACS Chemical Neuroscience·Alexander G ZestosRobert T Kennedy

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