Local control of murine subglottis development

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Leila A MankariousJennifer A Rudnick

Abstract

To determine if subglottic development is at least partially under local control and to determine which tissue layer(s) is predominantly responsible. The suglottises of 12 day-3 CD1 mice were grown in whole organ culture. The 12 subglottises were divided into 3 individual groups: +++, -++, and ---. Group+++ had all tissue layers of the subglottis intact: luminal epithelium, cricoid cartilage, inner and outer perichondrium. Group-++ had all layers intact with the exception of luminal epithelium. Group--- had all layers removed (luminal epithelium, inner and outer perichondrium) resulting in cricoid cartilage-only rings. All rings were grown in basic medium without the use of growth factors or serum for 15 days. Measurements of the rings were taken before and after organ culture growth. Group+++ was the only group that experienced growth. Only luminal growth was statistically significant although all rings experienced growth in both the luminal and external diameter. Group-++ did not experience any growth. Group--- lost structural integrity with collapse of the ring and did not experience growth of any dimension of the cartilage. Growth of the subglottis is under local control but may have additional influences from the outside t...Continue Reading

References

Sep 1, 1976·The Annals of Otology, Rhinology, and Laryngology·J L ParkinA L Jung
Aug 1, 1988·Journal of Pediatric Surgery·D S LoeffA Bahoric
Nov 1, 1987·The Annals of Otology, Rhinology, and Laryngology·D VolpiC P Kimmelman
Aug 1, 1982·Journal of Molecular and Cellular Cardiology·K H MooreF E Hull
Nov 26, 2002·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Leila A MankariousAllison B Adams

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Citations

Mar 25, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Efrain A Martinez-AlverniaLeila A Mankarious
Mar 23, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Efrain A Martinez-Alvernia, Leila A Mankarious
Sep 11, 2009·Proceedings of the American Thoracic Society·Carole L MarcusCarol J Blaisdell
Oct 31, 2013·American Journal of Respiratory and Critical Care Medicine·Ryan J AdamDavid A Stoltz
Nov 27, 2010·Paediatric Respiratory Reviews·Leila A Mankarious, Steven L Goudy

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Methods Mentioned

BETA
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