PMID: 9536211Jun 1, 1997Paper

Local control of ovarian steroidogenesis

Baillière's Clinical Obstetrics and Gynaecology
H D Mason, S Franks

Abstract

A number of putative paracrine factors are now thought to interact with FSH in the control of ovarian steroidogenesis. The relative importance of these factors remains to be determined, but the presence of the insulin-like growth factors and their binding proteins and the mechanism of control of the latter through the local production of proteases suggests a role for this system in folliculogenesis. We have demonstrated over-production of steroid hormones in tissue from women with polycystic ovaries. Theca cells in monolayer culture produced excessive amounts of progesterone and androstenedione and granulosa cell oestradiol production was considerably enhanced in response to FSH. Recent evidence points to a genetic defect in the expression or translation of steroidogenic hormones as a cause of excess androgen production, but the gene or genes involved has not been established. Data from our group suggest that granulosa cells from anovulatory polycystic ovaries are prematurely matured and we hypothesize that this is due to the interaction of the raised circulating insulin levels with LH in these follicles, an interaction that results in arrested follicular growth.

References

Apr 1, 1976·The New England Journal of Medicine·C R KahnJ Roth
May 1, 1979·American Journal of Obstetrics and Gynecology·E A WilsonK J Ryan
Mar 1, 1992·Human Reproduction·G F EricksonR J Chang
Jun 1, 1991·The Journal of Clinical Endocrinology and Metabolism·G LamsonR G Rosenfeld
Dec 1, 1991·British Journal of Cancer·O J OwensR E Leake
Jun 1, 1991·The Journal of Endocrinology·S Franks
Apr 1, 1990·The Journal of Clinical Endocrinology and Metabolism·G F EricksonR J Chang
Oct 1, 1989·The Journal of Clinical Endocrinology and Metabolism·G F EricksonD A Magoffin
Jul 1, 1989·Clinical Endocrinology·S Franks
Apr 1, 1989·The Journal of Clinical Endocrinology and Metabolism·A N PeirisA H Kissebah
Apr 16, 1988·Lancet·D W PolsonS Franks
Aug 1, 1988·Endocrine Reviews·W L Miller
Dec 1, 1988·Clinical Endocrinology·W M HagueH S Jacobs
May 1, 1988·The Journal of Clinical Endocrinology and Metabolism·D W PolsonV H James
Sep 1, 1987·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M G Hull
Sep 1, 1987·The Journal of Clinical Endocrinology and Metabolism·A DunaifA Dobrjansky
May 1, 1986·The Journal of Clinical Endocrinology and Metabolism·R L BarbieriK J Ryan
Jan 1, 1986·Journal of Cellular Biochemistry·R Derynck
Jul 1, 1972·Metabolism: Clinical and Experimental·M A Kirschner, C W Bardin

❮ Previous
Next ❯

Citations

Jun 5, 2002·Molecular and Cellular Endocrinology·Robert J Norman
Jun 3, 1999·Endocrinology and Metabolism Clinics of North America·R L Rosenfield
May 31, 2016·Fertility and Sterility·Uğur ÜnlütürkBulent Okan Yildiz
Apr 7, 2007·Alternatives to Laboratory Animals : ATLA·Alzbeta MlynarcíkováSona Scsuková
Apr 8, 2021·Reproductive Sciences·Matheus Credendio EirasCristiana Libardi Miranda Furtado

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.