Local Cortical Gyrification is Increased in Children With Autism Spectrum Disorders, but Decreases Rapidly in Adolescents

Cerebral Cortex
Jiwandeep S KohliRalph-Axel Müller

Abstract

Extensive MRI evidence indicates early brain overgrowth in autism spectrum disorders (ASDs). Local gyrification may reflect the distribution and timing of aberrant cortical expansion in ASDs. We examined MRI data from (Study 1) 64 individuals with ASD and 64 typically developing (TD) controls (7-19 years), and from (Study 2) an independent sample from the Autism Brain Imaging Data Exchange (n = 31/group). Local Gyrification Index (lGI), cortical thickness (CT), and surface area (SA) were measured. In Study 1, differences in lGI (ASD > TD) were found in left parietal and temporal and right frontal and temporal regions. lGI decreased bilaterally with age, but more steeply in ASD in left precentral, right lateral occipital, and middle frontal clusters. CT differed between groups in right perisylvian cortex (TD > ASD), but no differences were found for SA. Partial correlations between lGI and CT were generally negative, but associations were weaker in ASD in several clusters. Study 2 results were consistent, though less extensive. Altered gyrification may reflect unique information about the trajectory of cortical development in ASDs. While early overgrowth tends to be undetectable in later childhood in ASDs, findings may indicate ...Continue Reading

References

Jan 1, 1977·Annals of Neurology·J G ChiF H Gilles
Jan 1, 1988·Anatomy and Embryology·K ZillesH J Kretschmann
Jan 1, 1985·Brain, Behavior and Evolution·M A Hofman
Sep 1, 1995·Trends in Neurosciences·V S CavinessR S Nowakowski
Jan 1, 1995·Cerebral Cortex·E ArmstrongK Zilles
Oct 23, 1997·The Journal of Comparative Neurology·P R Huttenlocher, A S Dabholkar
Jun 10, 1998·Brain : a Journal of Neurology·A BaileyP Lantos
Feb 13, 2002·Neurology·Manuel F CasanovaEmil Roy
Aug 31, 2002·NeuroImage·Ruth A CarperEric Courchesne
Jul 17, 2003·JAMA : the Journal of the American Medical Association·Eric CourchesneNatacha Akshoomoff
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nitin GogtayPaul M Thompson
Sep 24, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elizabeth R SowellArthur W Toga
Oct 7, 2004·Psychiatry Research·Antonio Y HardanNancy J Minshew
Apr 27, 2005·NeuroImage·Moo K ChungAlan C Evans
Jun 7, 2005·Biological Psychiatry·Elizabeth Redcay, Eric Courchesne
Nov 25, 2005·Cerebral Cortex·Nouchine HadjikhaniHelen Tager-Flusberg
Jun 24, 2006·Neuropsychology Review·Julie A Alvarez, Eugene Emory
Jul 4, 2006·The American Journal of Psychiatry·Antonio Y HardanNancy J Minshew
Sep 16, 2006·Neuropathology and Applied Neurobiology·D P BuxhoevedenE Courchesne
Apr 27, 2007·The European Journal of Neuroscience·Praneshri Pillay, Paul R Manger
Oct 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christine Wu NordahlDavid C Van Essen
Mar 13, 2008·IEEE Transactions on Medical Imaging·Marie SchaerJean-Philippe Thiran
Apr 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip ShawSteve P Wise
Mar 21, 2009·Cerebral Cortex·Matthew S PanizzonWilliam S Kremen
Nov 28, 2009·Brain and Cognition·Tonya WhiteGuillermo Sapiro
Mar 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cynthia M SchumannEric Courchesne
Oct 12, 2010·Brain : a Journal of Neurology·Gregory L WallaceAlex Martin
May 4, 2011·Archives of General Psychiatry·Heather Cody HazlettJoseph Piven
May 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Armin RaznahanJay N Giedd
Feb 15, 2012·Human Brain Mapping·Shu SuGuillermo Sapiro
May 1, 2012·Translational Neuroscience·Emily L WilliamsManuel F Casanova
Jun 8, 2012·Autism Research : Official Journal of the International Society for Autism Research·Mahsa ShokouhiBarrie Condon

❮ Previous
Next ❯

Citations

Oct 10, 2019·Psychiatry and Clinical Neurosciences·Daiki SasabayashiMichio Suzuki
Sep 3, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Alex M PagnozziStephen E Rose
Aug 21, 2019·Frontiers in Neuroscience·Shoujun XuGuihua Jiang
Jul 1, 2020·Translational Psychiatry·Angeline MihailovVincent Frouin
Nov 25, 2019·Neuroimaging Clinics of North America·Jessica B Girault, Joseph Piven
Mar 30, 2021·Neuroscience Bulletin·Xiaoyi LiHong Zhang
May 8, 2021·Frontiers in Psychiatry·Mingmin NingJingyi Fan
Jul 27, 2021·Autism Research : Official Journal of the International Society for Autism Research·Silvia AlemanyTonya White
Aug 11, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Lin LiYiyong Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.