Local delivery of argatroban for the prevention of restenosis after coronary balloon angioplasty: a prospective randomized pilot study

Circulation Journal : Official Journal of the Japanese Circulation Society
Tomonori Itoh3D-CAT Investigators

Abstract

Effective pharmacological prevention of restenosis using the systemic administration of various drugs that were effective for the prevention of restenosis in experimental studies has not been reported. The purpose of this study was to evaluate whether the local delivery of a potent thrombin inhibitor, argatroban, using a local drug delivery device would prevent restenosis after plain old balloon angioplasty (POBA). Seventy patients with chronic coronary artery disease requiring POBA were randomly assigned to wither the control group (n=35) or the argatroban group (n=35). In the argatroban group, argatroban was administered intravenously for 30 min before the POBA and intracoronarily into the dilated site using a Dispatch catheter immediately after the POBA, followed by a postoperative intravenous infusion for 4 h. The angiographical lesion restenosis and clinical restenosis rates at follow-up were significantly lower in the argatroban group (27% and 14%) than in the control group (56% and 37%; p=0.02 and p=0.03, respectively). There was no major complication during the procedure. The local delivery of argatroban is safe and effective in preventing restenosis after balloon angioplasty.

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Citations

Jul 1, 2006·Future Cardiology·Jawed FareedJeanine M Walenga
Sep 14, 2012·Expert Opinion on Drug Metabolism & Toxicology·Ignacio Cruz-GonzálezBryan P Yan
Dec 24, 2005·Expert Opinion on Pharmacotherapy·Michael V SerebruanyVictor L Serebruany
Nov 21, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Yoshihiro MorinoTakeshi Kimura
Feb 23, 2005·Expert Review of Cardiovascular Therapy·Marian P LaMonteMarcie J Hursting
Dec 26, 2006·Expert Review of Cardiovascular Therapy·Bruce E Lewis, Marcie J Hursting
Nov 19, 2010·Expert Review of Hematology·Walter P JeskeJeanine M Walenga

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