Local delivery of COMP-angiopoietin 1 accelerates new bone formation in rat calvarial defects

Journal of Biomedical Materials Research. Part a
Shin-Saeng LimJeong-Chae Lee

Abstract

Recombinant COMP-Ang1, a chimera of angiopoietin-1 (Ang1) and a short coiled-coil domain of cartilage oligomeric matrix protein (COMP), is under consideration as a therapeutic agent in bone reconstruction. However, the potential of COMP-Ang1 to regenerate impaired bone and induce new bone formation has not been completely explored. In this study, male Sprague-Dawley rats underwent calvarial defect surgery and divided into two groups: scaffold treatment alone (control group) and COMP-Ang1-impregnated scaffold (COMP-Ang1 group). According to live micro-CT and histological analyses, the COMP-Ang1 group showed greater new bone formation and maturation than did the control both four and eight weeks after surgery. The values of bone volume, bone mineral density, and bone surface were also higher in the COMP-Ang1 group than in the control at the same weeks after surgery. In addition, the delivery of COMP-Ang1 facilitated significantly the expression of osteoblast-specific markers such as runt-related transcription factor 2 (p < 0.001), osterix (p < 0.001), bone morphogenetic protein-2 (p < 0.001), alkaline phosphatase (p < 0.01), osteocalcin (p < 0.001), and type I collagen (p < 0.05) in newly formed bone, compared with the control. I...Continue Reading

References

Oct 1, 1988·Journal of Biomedical Materials Research·S T BoyceJ F Hansbrough
Oct 17, 1998·Science·C SuriG D Yancopoulos
Oct 8, 2003·Current Pharmaceutical Design·J B Lian, G S Stein
Dec 4, 2003·Drug Discovery Today·Richard A D Carano, Ellen H Filvaroff
Apr 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chung-Hyun ChoGou Young Koh
Apr 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chung-Hyun ChoGou Young Koh
Mar 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Chung-Hyun ChoGou Young Koh
Apr 15, 2006·The Journal of Biological Chemistry·Eun-Joo JeonSuk-Chul Bae
Aug 5, 2006·Journal of Cellular Biochemistry·Bruno NerviJohn F DiPersio
Sep 11, 2007·Biochemical and Biophysical Research Communications·Toru SuzukiToshio Suda
Feb 2, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Tara AghalooZhiyuan Zhang
Sep 30, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Jee-Hee JungKyoo-Sung Cho
Feb 26, 2013·Current Pharmaceutical Design·Quanjun CuiJames N Irvine
Jun 6, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christopher J Percival, Joan T Richtsmeier
Apr 16, 2014·Journal of Nanoscience and Nanotechnology·Liliana Polo-CorralesJaime E Ramirez-Vick
Apr 29, 2014·Dental Materials : Official Publication of the Academy of Dental Materials·Kangwon LeeHockin H K Xu

❮ Previous
Next ❯

Citations

Jul 24, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Cong LuoHong An
Oct 22, 2016·Journal of Bone and Mineral Metabolism·Sher Bahadur PoudelJeong-Chae Lee
Oct 28, 2019·Zeitschrift für Gerontologie und Geriatrie·Tao SunMin Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Chung-Hyun ChoGou Young Koh
Clinical and Experimental Pharmacology & Physiology
Ying YinDengshun Miao
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Tao WangDaniel D Bikle
© 2022 Meta ULC. All rights reserved