Local delivery of hormonal therapy with silastic tubing for prevention and treatment of breast cancer

Scientific Reports
Jeenah ParkPamela N Munster

Abstract

Broad use of germline testing has identified an increasing number of women at risk for breast cancer with a need for effective chemoprevention. We report a novel method to selectively deliver various anti-estrogens at high drug levels to the breast tissue by implanting a device comprised of silastic tubing. Optimized tubing properties allow elution of otherwise poorly bioavailable anti-estrogens, such as fulvestrant, into mammary tissue in vitro and in vivo with levels sufficient to inhibit estrogen receptor activation and tumor cell proliferation. Implantable silastic tubing delivers fulvestrant selectively to mouse mammary fat tissue for one year with anti-tumor effects similar to those achieved with systemic fulvestrant exposure. Furthermore, local delivery of fulvestrant significantly decreases cell proliferation, as assessed by Ki67 expression, most effectively in tumor sections adjacent to tubing. This approach may thereby introduce a potential paradigm shift and offer a promising alternative to systemic therapy for prevention and early interception of breast cancer.

References

Oct 1, 1978·Contraception·H A NashL E Atkinson
Dec 1, 1982·Clinical Endocrinology·C G NilssonT Luukkainen
May 17, 1995·Journal of the National Cancer Institute·C K OsborneR I Nicholson
May 29, 1997·International Journal of Cancer. Journal International Du Cancer·P D PharoahB A Ponder
Apr 20, 2004·British Journal of Cancer·J F R Robertson, M Harrison
Nov 16, 2004·Cancer Treatment Reviews·John F R Robertson
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philippe RouanetThierry Maudelonde
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy L KeatingMatthew R Smith
Apr 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sining Chen, Giovanni Parmigiani
Jun 15, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony V D'AmicoPhilip W Kantoff
Feb 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Noah D KauffTimothy R Rebbeck
Jun 26, 2008·Human Genetics·Philippe M CampeauMarc D Tischkowitz
Aug 8, 2008·Future Oncology·Andrew J RothChristian J Nelson
Nov 11, 2008·Nature Biotechnology·Mark R Prausnitz, Robert Langer
Sep 3, 2010·JAMA : the Journal of the American Medical Association·Susan M DomchekTimothy R Rebbeck
Oct 20, 2010·Journal of the National Cancer Institute. Monographs·E Shelley Hwang
Jul 17, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Oukseub LeeSeema A Khan
Oct 24, 2014·Annual Review of Medicine·Christopher J LordAlan Ashworth
Jan 22, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S Shiovitz, L A Korde
Apr 29, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey S WeberMary L Disis
Apr 30, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L ApetohF Ghiringhelli
Jun 28, 2015·The Patient·Kathryn A MartinezSarah T Hawley
Jul 19, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Geoffrey KimRichard Pazdur
Oct 2, 2015·Journal of the National Cancer Institute·Mathias WorniE Shelley Hwang
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Aug 26, 2017·Plastic and Reconstructive Surgery·Scott ThomasPamela N Munster

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
xenografts
xenograft
Assay
Protein Assay

Software Mentioned

Analyst
ImageScope
Moverover
Immunoratio

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.