Local delivery of sirolimus nanoparticles for the treatment of in-stent restenosis

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Alexandre C ZagoAlcides J Zago

Abstract

To test the local delivery of sirolimus nanoparticles following percutaneous transluminal coronary angioplasty (PTCA) to treat in-stent restenosis (ISR) in a swine model. Coronary bare-metal stent (BMS) implantation reduces major adverse cardiac events when compared with PTCA; however, ISR rates remain high. Eighteen swine underwent BMS deployment guided by intravascular ultrasound (IVUS). Of these, 16 developed ISR (1 stent/swine) and underwent angioplasty with a noncompliant balloon (PTCA-NC). The animals were then randomized into four groups for local infusion of sirolimus nanoparticles through a porous balloon catheter, as follows: (1) PTCA-NC alone (control); (2) PTCA-NC + (polylactic acid)-based nanoparticle formulation (anionic 1); (3) PTCA-NC + (polylactic-co-glycolic acid)-based nanoparticle formulation (anionic 2); and (4) PTCA-NC + Eudragit RS nanoparticle formulation (cationic). Coronary angiography and IVUS follow-up were performed 28 days after ISR treatment. There was one episode of acute coronary occlusion with the cationic formulation. Late area loss was similar in all groups at 28 days according to IVUS. However, luminal volume loss (control = 20.7%, anionic 1 = 4.0%, anionic 2 = 6.7%, cationic = 9.6%; P = 0.0...Continue Reading

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Citations

Mar 12, 2016·Pharmaceutical Research·Hoai X Nguyen, Edgar A O'Rear
May 31, 2016·The American Journal of Cardiology·Fernando AlfonsoJosé R López-Minguez
Jun 1, 2016·The American Journal of Cardiology·Alexandre do Canto Zago, Bruno da Silva Matte
Nov 23, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jian ZhaoQing Liu
Dec 1, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Azadeh HaeriSimin Dadashzadeh
Sep 19, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Krzysztof MilewskiPaweł E Buszman
Dec 7, 2018·Frontiers in Pharmacology·Hannah A StrobelMarsha W Rolle
Jul 13, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Victor Segura-IbarraElvin Blanco
Sep 16, 2014·ACS Nano·Lee-Chun SuKytai T Nguyen

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