Local-dependency of morphological and optical properties between breast cancer cell lines

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Seung Ho LeeJun Ki Kim

Abstract

Breast cancer is the most malignant type of cancer in women and is a global health problem, with mortality by metastasis being the main factor among others. Currently, detection and diagnosis of breast cancer is achieved through a variety of procedures, such as clinical examination, medical imaging, biopsy, and histopathological analysis. In contrast, spectroscopic analysis has a variety of advantages such as being noninvasive, not destroying biological materials, and not requiring additional histological analysis. In this study, various approaches using Raman spectroscopy, atomic force microscopy (AFM), and optical microscopy were used together to differentiate between and characterize normal breast cell lines (MCF-10A) and breast cancer cell lines (MDA-MB-231, MDA-MB-453). Raman spectra of normal breast cell and breast cancer cell lines confirmed visual differences in the concentrations of various compounds. These spectra were also analyzed using principle component analysis (PCA), and the PCA results showed reliable separation of the three cell lines and the cancer cell lines (MDA-MB-231, MDA-MB-453). With these results, optically synchronizing the AFM morphology, the Raman spectroscopy, and the visible RGB optical transmiss...Continue Reading

Citations

Feb 5, 2019·GeroScience·Lisa LiendlMarkus Schosserer
Jul 12, 2019·Cancer Research·Santanu BhattacharyaDebabrata Mukhopadhyay
Jan 6, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Venzil Lavie DsouzaShama Prasada Kabekkodu

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