Local effects of octreotide on glutamate-evoked activation of Adelta and C afferent fibers in rat hairy skin

Brain Research
Rong LuoYan Zhao

Abstract

The aim of the present study was to investigate whether local application of octreotide, an analogue of somatostatin, suppresses the glutamate-evoked activities of Adelta and C primary afferent fibers innervating dorsal hairy skin of the rat in vivo. The single unit activity of Adelta and C afferent fibers was recorded in isolated filaments from the dorsal cutaneous branches of the T9-T12 spinal nerves. Changes in discharge relative to baseline during injection of glutamate (0.3mM, 10microL) into the receptive field with pretreatment by octreotide (20microM, 10microL) were compared with injection after pretreatment with normal saline. Most of Adelta fibers (21/27, 78%) and C fibers (21/26, 81%) in the dorsal cutaneous branches were significantly activated by local injection of glutamate following saline injection. The mean discharge rates increased from 2.39+/-0.30 and 2.42+/-0.37 impulses/min to 12.79+/-2.04 and 13.56+/-2.56 impulses/min during injection of glutamate for Adelta and C fibers, respectively. After octreotide pretreatment group, glutamate increased the mean discharge rates from 1.93+/-0.38 and 2.25+/-0.29 impulses/min to 6.11+/-0.9 and 6.31+/-1.18 impulses/min in Adelta fibers and C fibers, respectively. The disch...Continue Reading

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Citations

May 16, 2013·Chinese Journal of Integrative Medicine·Wei-Bo ZhangFuxe Kjell
May 21, 2011·Clinical and Experimental Pharmacology & Physiology·Jun WangYan Zhao
Feb 2, 2013·The Journal of Investigative Dermatology·Trisia BreitkopfKevin J McElwee

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