Local effects of pregnancy on connexin proteins that mediate Ca2+-associated uterine endothelial NO synthesis

Hypertension
Timothy J MorschauserR R Magness

Abstract

Uterine artery adaptations during gestation facilitate increases in uterine blood flow and fetal growth. local expression and distribution of uterine artery connexins play roles in mediating in vivo gestational eNOS activation and NO production. We established an ovine model restricting pregnancy to a single uterine horn and measured uterine blood flow, uterine artery shear stress, connexins 37/43, and P(635)eNOS protein levels in uterine artery and systemic artery (omental and renal) endothelium and connexins in vascular smooth muscle. Uterine blood flow and shear stress were locally (unilaterally) and substantially elevated by gestation. During pregnancy, uterine artery endothelial gap junction proteins connexins 37/43 were locally regulated in the gravid horn and elevated 10.3- and 25.6-fold; uterine artery endothelial P(635)eNOS and total eNOS were elevated 3.3- and 2.9-fold; whereas uterine artery vascular smooth muscle connexins 37/43 were locally elevated 12.5- and 5.9-fold, respectively. Less pronounced changes were observed in systemic vasculature except for significant pregnancy-associated increases in omental artery vascular smooth muscle connexin 43 and omental artery endothelial P(635)eNOS and total eNOS. Gap junct...Continue Reading

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Citations

Oct 13, 2016·The Journal of Endocrinology·D S Boeldt, I M Bird
Feb 1, 2017·Journal of Cardiovascular Pharmacology·Jude S MortonSandra T Davidge
Sep 25, 2017·Current Hypertension Reports·George OsolMaurizio Mandalà
Nov 12, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Derek S BoeldtIan M Bird
Aug 31, 2016·Hypertension·Bryan C AmpeyRonald R Magness
Feb 12, 2019·Annual Review of Physiology·George OsolMaurizio Mandalà
Apr 12, 2020·International Journal of Molecular Sciences·Maurizio Mandalà
May 19, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Nga Ling KoGeorge Osol

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