Local elevation of the anti-inflammatory interleukin-10 in the pathogenesis of chronic subdural hematoma

Neurosurgical Review
Tsukasa WadaShigeatsu Endo

Abstract

We investigated the relationship between inflammatory and anti-inflammatory cytokines in the pathogenesis of chronic subdural hematoma (CSDH) by measuring the plasma and subdural fluid levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10). The levels of IL-6, IL-8 and IL-10 were measured in the subdural fluid obtained from 34 patients with CSDH, using the enzyme-linked immunosorbent assay. The patients were classified into a high IL-10 group and a low IL-10 group according to the level of IL-10 in their subdural fluid samples. The subdural fluid levels of IL-6 and IL-8 were significantly higher in the high IL-10 group than in the low IL-10 group (P<0.05). A tendency for the patients in the low IL-10 group to show the separated or layer type of pattern on the CT scans was noted.

References

May 1, 1991·The Anatomical Record·D E Haines
Sep 1, 1988·Surgical Neurology·H ItoT Hasegawa
May 1, 1981·Journal of Neurosurgery·T M Markwalder
Sep 1, 1981·Journal of Neurosurgery·T M MarkwalderH Markwalder
Jan 1, 1994·British Journal of Neurosurgery·S A RossB J Rowlands
Jan 1, 1993·Neurosurgery·D E HainesO al-Mefty
Jan 1, 1996·Annual Review of Immunology·M FeldmannR N Maini
Apr 2, 1998·Acta neurochirurgica·M SuzukiA Ogawa
Jul 17, 2001·IMA Journal of Mathematics Applied in Medicine and Biology·R M Seymour, B Henderson
Jun 21, 1963·Wiener klinische Wochenschrift·D W KRUGER
Apr 1, 1963·Archives of Neurology·C L GOODELL, J MEALEY

❮ Previous
Next ❯

Citations

Apr 25, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Milo StanisicTerje Sæhle
Nov 26, 2013·Journal of the Neurological Sciences·Dong WangJianning Zhang
Apr 30, 2014·Journal of the Neurological Sciences·Tuo LiJianning Zhang
Oct 4, 2016·Asian Journal of Neurosurgery·Yad R YadavJitin Bajaj
Nov 28, 2012·Neurologia Medico-chirurgica·Masatoshi KitazonoAkira Teramoto
Jun 1, 2017·Journal of Neuroinflammation·Ellie EdlmannPeter J Hutchinson
Apr 12, 2019·Scientific Reports·Ellie EdlmannUNKNOWN Dex-CSDH trial collaborative and BNTRC collaborative.
Dec 6, 2018·Trials·Angelos G KoliasUNKNOWN British Neurosurgical Trainee Research Collaborative (BNTRC) and Dex-CSDH Trial Collaborators
Apr 12, 2021·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Olufemi Emmanuel IdowuJulius Mautin Vitowanu
May 18, 2018·World Neurosurgery·Dana C HollUNKNOWN Dutch Chronic Subdural Hematoma Research Group (DSHR)

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.