Local endometrial injury in women with failed IVF undergoing a repeat cycle: A randomized controlled trial

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Aleyamma TkKorula George

Abstract

To evaluate the effectiveness of local endometrial injury in women undergoing in vitro fertilization (IVF) with at least one previous unsuccessful attempt. Randomized controlled trial. Recruited women were randomized into two groups. In group A (pipelle group), women underwent pipelle biopsy twice in the luteal phase in the cycle prior to IVF. In group B (control), women did not undergo any intervention prior to IVF. The primary outcome was clinical pregnancy rate. The secondary outcomes included live birth, miscarriage, multiple pregnancy and preterm delivery rates. One hundred and eleven women were included in the study with 55 in the pipelle group and 56 in the control arm. The baseline clinical characteristics were similar in both groups. The clinical pregnancy rates were not significantly different between pipelle and control group (34.09% vs. 27.65%; Odds ratio, OR 1.35, 95% confidence interval, CI 0.55-3.30). The live birth (31.81% vs. 25.53%; OR 1.36, 95% CI 0.55-3.39), multiple pregnancy (33.33% vs. 61.54%; OR 0.31, 95% CI 0.07-1.47), miscarriage (6.66% vs. 7.69%; OR 0.86, 95% CI 0.05-15.23) and preterm delivery rates (35.71% vs. 66.66%; OR 0.28, 95% CI 0.05-1.4) were also not significantly different between the two gr...Continue Reading

Citations

Jun 12, 2018·Current Opinion in Obstetrics & Gynecology·José Bellver, Carlos Simón
Nov 6, 2018·Human Reproduction Update·Chen Sar-Shalom NahshonMartha Dirnfeld
Feb 11, 2019·European Journal of Clinical Investigation·Antonis MakrigiannakisTimur Gurgan
May 7, 2020·Human Reproduction·S MackensS Santos-Ribeiro
Jan 14, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hsiao-Wen TsaiKuan-Hao Tsui
Nov 13, 2019·Human Reproduction Update·Amerigo VitaglianoAttilio Di Spiezio Sardo
Mar 22, 2019·Human Reproduction Open·N E van HoogenhuijzeH L Torrance
Jan 21, 2019·Archives of Gynecology and Obstetrics·Jennifer HiltonJon Havelock
Oct 20, 2020·Reproductive Medicine and Biology·Chen NahshonMartha Dirnfeld
Jul 1, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sine BerntsenAnja Pinborg
Mar 21, 2021·Human Reproduction·Amerigo VitaglianoPantaleo Greco
Jun 3, 2021·Journal of Clinical Medicine·Ioannis RigosCharalampos Siristatidis
Jun 11, 2021·The Cochrane Database of Systematic Reviews·Sarah F LensenWellington P Martins
Jul 20, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Xiao Han, Linli Hu

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