Local erythropoietin injection in tibiofibular fracture healing

Trauma Monthly
Hooman BakhshiFarshad Safdari

Abstract

Erythropoietin (EPO), in addition to its function as an erythropoiesis regulator has a regenerative activity on some nonhematopoietic tissues. Animal studies have suggested a role for erythropoietin in bone healing. The present study aimed to evaluate the effects of local EPO injection in healing of tibiofibular fractures. In a prospective double blind study, 60 patients with tibiofibular fracture were divided to equal EPO or placebo groups, randomly. Patients received local injection of either EPO or a placebo to the site of fracture two weeks after surgical fixation. Patients were followed by clinical and radiographic examination to determine the union rate. The period of fracture union and incidence of nonunion were compared between the two groups. The demographic data and types of fractures were similar in the both groups. The mean duration of the fracture union was 2.1 weeks shorter in those treated with EPO (P = 0.01). Nonunion was observed in 6 patients of the control group and 2 receiving EPO (P = 0.02). No patient experienced any adverse effect from local EPO injections. EPO injection into the site of tibiofibular fractures may possibly accelerate healing.

References

Jul 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·John StreetEllen H Filvaroff
Dec 11, 2002·The Journal of Bone and Joint Surgery. American Volume·Shunmugam GovenderUNKNOWN BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group
Jun 29, 2004·Journal of Bone and Mineral Metabolism·Wei-Jia ChenYukihide Iwamoto
Nov 9, 2004·Developmental Biology·Nathalie KerteszHong Wu
May 12, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hali WangJames T Ryaby
Jun 8, 2006·The Journal of Bone and Joint Surgery. American Volume·Marc F SwiontkowskiAmratlal Patel
Sep 19, 2009·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Brandon BeamerJoseph Lane
Nov 13, 2009·Molecular and Cellular Biochemistry·Ward De SpiegelaereWim Van den Broeck

❮ Previous
Next ❯

Citations

Dec 19, 2013·Trauma Monthly·Jan Hendrik Duedal Rölfing, Cody Bünger
Jan 15, 2015·Journal of Dental Research·C LiH Sun
Oct 19, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hallgerdur Lind KristjansdottirDan Mellström
Jan 30, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sahar Hiram-BabYankel Gabet
Feb 11, 2020·Frontiers in Physiology·Sukanya SureshConstance T Noguchi
Jun 27, 2019·Journal of Orthopaedic Surgery·Ahmet OztermeliBurak Yagmur Ozturk
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Fedor SenatovAnna Karyagina
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Sukanya SureshConstance Tom Noguchi

❮ Previous
Next ❯

Software Mentioned

BESTT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.