Local Extravascular Growth Factor Delivery in Myocardial Ischemia

Drug Delivery
J J Lopez, M Simons

Abstract

A number of angiogenic growth factors have been demonstrated in vivo to promote angiogenesis in ischemic myocardium, including basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF). We used the porcine ameroid constrictor model to simulate chronic ischemia in an effort to study the role of exogenous growth factor delivery in the development of coronary collateral circulation. Heparin alginate microspheres were used to deliver bFGF, while an implantable osmotic pump was used for VEGF delivery. Anti-von Willebrand antibody staining was used to visualize microvessels in the porcine heart sections obtained from both ischemic and non-ischemic myocardium. A significant increase in the number of microvessels in growth factor-treated pigs compared to control animals was noted. Myocardial blood flow was used to determine the physiologic impact of these findings. In bFGF and VEGF treated animals resting collateral flow values significantly exceeded those of the control group. In addition, both bFGF and VEGF administration resulted in improvements in myocardial perfusion sufficient to prevent stress-induced deterioration of myocardial performance. Results of the studies demonstrate that local perivascular dru...Continue Reading

References

Dec 1, 1992·Circulation Research·F C WhiteC M Bloor
Jan 1, 1991·Annals of the New York Academy of Sciences·G MazuéR Roncucci
Nov 22, 1991·Science·P CuevasG Giménez-Gallego
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1989·Growth Factors·G F WhalenJ Folkman
Mar 17, 1988·Nature·M B Sporn, A B Roberts
Jul 1, 1988·Progress in Cardiovascular Diseases·W SchaperJ Schaper
Feb 1, 1987·British Heart Journal·M FujitaH Asanoi
Dec 1, 1993·Journal of the American College of Cardiology·A BattlerM Eldar
Aug 1, 1994·The Journal of Clinical Investigation·K HaradaM Simons
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E R EdelmanM J Karnovsky

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