Local field potential activity dynamics in response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease.

Neurobiology of Disease
C WiestF Torrecillos

Abstract

Local field potentials (LFPs) may afford insight into the mechanisms of action of deep brain stimulation (DBS) and potential feedback signals for adaptive DBS. In Parkinson's disease (PD) DBS of the subthalamic nucleus (STN) suppresses spontaneous activity in the beta band and drives evoked resonant neural activity (ERNA). Here, we investigate how STN LFP activities change over time following the onset and offset of DBS. To this end we recorded LFPs from the STN in 14 PD patients during long (mean: 181.2 s) and short (14.2 s) blocks of continuous stimulation at 130 Hz. LFP activities were evaluated in the temporal and spectral domains. During long stimulation blocks, the frequency and amplitude of the ERNA decreased before reaching a steady state after ~70 s. Maximal ERNA amplitudes diminished over repeated stimulation blocks. Upon DBS cessation, the ERNA was revealed as an under-damped oscillation, and was more marked and lasted longer after short duration stimulation blocks. In contrast, activity in the beta band suppressed within 0.5 s of continuous DBS onset and drifted less over time. Spontaneous activity was also suppressed in the low gamma band, suggesting that the effects of high frequency stimulation on spontaneous osc...Continue Reading

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Citations

Dec 11, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Abteen MostofiErlick A C Pereira
Oct 10, 2020·Brain Stimulation·Stephen L SchmidtWarren M Grill
May 2, 2021·Neurobiology of Disease·Zixiao YinJianguo Zhang
Jul 16, 2021·Neurodegenerative Disease Management·Daniel SiricaKarlo J Lizárraga

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Software Mentioned

MATLAB
MathWorks
TMSi Porti
Renishaw Neuroinspire
ERNA
Lead

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