Local field potential decoding of the onset and intensity of acute pain in rats

Scientific Reports
Qiaosheng ZhangJing Wang

Abstract

Pain is a complex sensory and affective experience. The current definition for pain relies on verbal reports in clinical settings and behavioral assays in animal models. These definitions can be subjective and do not take into consideration signals in the neural system. Local field potentials (LFPs) represent summed electrical currents from multiple neurons in a defined brain area. Although single neuronal spike activity has been shown to modulate the acute pain, it is not yet clear how ensemble activities in the form of LFPs can be used to decode the precise timing and intensity of pain. The anterior cingulate cortex (ACC) is known to play a role in the affective-aversive component of pain in human and animal studies. Few studies, however, have examined how neural activities in the ACC can be used to interpret or predict acute noxious inputs. Here, we recorded in vivo extracellular activity in the ACC from freely behaving rats after stimulus with non-noxious, low-intensity noxious, and high-intensity noxious stimuli, both in the absence and chronic pain. Using a supervised machine learning classifier with selected LFP features, we predicted the intensity and the onset of acute nociceptive signals with high degree of precision....Continue Reading

References

Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·G C DeAngelisR D Freeman
Oct 9, 1999·Journal of Neurophysiology·R C CoghillM J Iadarola
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·J P JohansenB H Manning
Nov 1, 1954·Journal of Neurophysiology·J D GREEN, A A ARDUINI
May 16, 2006·Lancet·Henrik KehletClifford J Woolf
Apr 26, 2007·PLoS Biology·Joachim GrossMarkus Ploner
Jul 17, 2007·Journal of Pain and Symptom Management·Ian KudelSrinivasa N Raja
Apr 24, 2009·Journal of Visualized Experiments : JoVE·David P NguyenMatthew A Wilson
Sep 29, 2009·Nature Neuroscience·Tamara KingFrank Porreca
Jul 20, 2010·Journal of Neuroscience Methods·Hemant BokilPartha P Mitra
Aug 28, 2010·The Journal of Bone and Joint Surgery. British Volume·C E H ScottL C Biant
May 19, 2012·Nature Reviews. Neuroscience·György BuzsákiChristof Koch
Jun 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Z G ZhangG D Iannetti
Jun 19, 2012·Neuroscience Letters·Petra Schweinhardt, M Catherine Bushnell
Jun 19, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·S M HatemA Mouraux
Jul 4, 2012·Nature Neuroscience·Marwan N BalikiA Vania Apkarian
Apr 12, 2013·The New England Journal of Medicine·Tor D WagerEthan Kross
Dec 1, 2014·Biological Psychiatry·Florent BarthasIpek Yalcin
Mar 11, 2015·Cerebral Cortex·Enrico SchulzMarkus Ploner
Apr 4, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michelle LeeJing Wang
Apr 15, 2015·NeuroImage·Tomislav MilekovicThomas Brochier
May 8, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Edita NavratilovaFrank Porreca
Feb 13, 2016·Frontiers in Computational Neuroscience·Weiwei Peng, Dandan Tang
May 6, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philipp Taesler, Michael Rose
Jun 14, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yongzhi HuangShouyan Wang
Dec 28, 2016·Trends in Cognitive Sciences·Markus PlonerJoachim Gross
Apr 7, 2017·Journal of Neural Engineering·Zhe ChenJing Wang
May 20, 2017·ELife·Qiaosheng ZhangJing Wang

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Citations

Sep 13, 2018·Journal of Computational Neuroscience·Zhengdong XiaoZhe Chen
May 21, 2019·Frontiers in Cellular Neuroscience·Zhengdong XiaoZhe Sage Chen
Oct 6, 2021·Journal of Neural Engineering·Zhe Sage Chen

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