May 10, 2016

Local field potentials primarily reflect inhibitory neuron activity in human and monkey cortex

BioRxiv : the Preprint Server for Biology
Bartosz TelenczukAlain Destexhe

Abstract

The local field potential (LFP) is generated by large populations of neurons, but unitary contribution of spiking neurons to LFP is not well characterized. We investigated this contribution in multi-electrode array recordings from the cerebral cortex of human and monkey by calculating the spike-triggered LFP average (st-LFP). The resulting st-LFPs were dominated by broad spatio-temporal components due to on-going activity, synaptic inputs and recurrent connectivity. To observe the local field of a single spike we applied spatial filtering. The filtered st-LFPs were limited to an area of 800 μm from the neuron, and propagated at axonal speed, which is consistent with their unitary nature. In addition, we discriminated between putative inhibitory and excitatory neurons and found that the former dominated this unitary LFP contribution, consistently with previous findings in hippocampal slices. Thus, in human and monkey cortex, the LFP may primarily reflect inhibitory neuron activity.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Cortex Bone Disorders
Adrenal Cortex Diseases
Neurons
Spatial Distribution
Field's stain
LMNA
Lymphocytosis-Promoting Factor-Hemagglutinin
Synapses
Monkeys
Local

About this Paper

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.