Local frequency dependence in transcranial ultrasound transmission.

Physics in Medicine and Biology
P J WhiteK Hynynen

Abstract

The development of large-aperture multiple-source transducer arrays for ultrasound transmission through the human skull has demonstrated the possibility of controlled and substantial acoustic energy delivery into the brain parenchyma without the necessitation of a craniotomy. The individual control of acoustic parameters from each ultrasound source allows for the correction of distortions arising from transmission through the skull bone and also opens up the possibility for electronic steering of the acoustic focus within the brain. In addition, the capability to adjust the frequency of insonation at different locations on the skull can have an effect on ultrasound transmission. To determine the efficacy and applicability of a multiple-frequency approach with such a device, this study examined the frequency dependence of ultrasound transmission in the range of 0.6-1.4 MHz through a series of 17 points on four ex vivo human skulls. Effects beyond those that are characteristic of frequency-dependent attenuation were examined. Using broadband pulses, it was shown that the reflected spectra from the skull revealed information regarding ultrasound transmission at specific frequencies. A multiple-frequency insonation with optimized f...Continue Reading

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Citations

Feb 6, 2013·ACS Chemical Neuroscience·Alison Burgess, Kullervo Hynynen
Sep 3, 2011·Nature Protocols·Yusuf TufailWilliam J Tyler
Apr 7, 2007·Topics in Magnetic Resonance Imaging : TMRI·Phillip Jason White
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May 3, 2015·IEEE Transactions on Bio-medical Engineering·Tengfei GuoShanbao Tong
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Sep 24, 2016·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Nicholas P K Ellens, Ari Partanen
Aug 5, 2017·Journal of Neural Engineering·Jerel K MuellerWynn Legon
Dec 22, 2009·Expert Review of Medical Devices·Rodrigo C L EdelmuthFelipe Fregni
Jun 3, 2020·Journal of Neural Engineering·Cristina PasquinelliAxel Thielscher
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Jan 31, 2018·Human Brain Mapping·Wynn LegonJerel K Mueller
Dec 14, 2017·Journal of Neural Engineering·Camilo RojasRoberto Raiteri
May 7, 2021·Research : a Science Partner Journal·Tianyuan BianHairong Zheng

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