Local functional connectivity alterations in schizophrenia, bipolar disorder, and major depressive disorder

Journal of Affective Disorders
Yange WeiFei Wang

Abstract

Local functional connectivity (FC) indicates local or short-distance functional interactions and may serve as a neuroimaging marker to investigate the human brain connectome. Local FC alterations suggest a disrupted balance in the local functionality of the whole brain network and are increasingly implicated in schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). We aim to examine the similarities and differences in the local FC across SZ, BD, and MDD. In total, 537 participants (SZ, 126; BD, 97; MDD, 126; and healthy controls, 188) completed resting-state functional magnetic resonance imaging at a single site. The local FC at resting state was calculated and compared across SZ, BD, and MDD. The local FC increased across SZ, BD, and MDD within the bilateral orbital frontal cortex (OFC) and additional region in the left OFC extending to putamen and decreased in the primary visual, auditory, and motor cortices, right supplemental motor area, and bilateral thalami. There was a gradient in the extent of alterations such that SZ > BD > MDD. This cross-sectional study cannot consider medications and other clinical variables. These findings indicate a disrupted balance between network integration and segrega...Continue Reading

Citations

Oct 4, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Linda A AntonucciNikolaos Koutsouleris
Dec 29, 2020·Frontiers in Neuroscience·Ruiqi FengFei Wang
Mar 24, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Du LeiMelissa P DelBello
May 15, 2021·PloS One·Kyungwon KimBoreom Lee
May 7, 2019·Journal of Affective Disorders·Alessio SimonettiKirti Saxena
Jul 5, 2021·World Neurosurgery·Tyler ScullenRobert F Dallapiazza
Aug 7, 2021·Brain Sciences·Marta PrietoAntonio Ibáñez-Molina

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