Abstract
Local functional connectivity (FC) indicates local or short-distance functional interactions and may serve as a neuroimaging marker to investigate the human brain connectome. Local FC alterations suggest a disrupted balance in the local functionality of the whole brain network and are increasingly implicated in schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). We aim to examine the similarities and differences in the local FC across SZ, BD, and MDD. In total, 537 participants (SZ, 126; BD, 97; MDD, 126; and healthy controls, 188) completed resting-state functional magnetic resonance imaging at a single site. The local FC at resting state was calculated and compared across SZ, BD, and MDD. The local FC increased across SZ, BD, and MDD within the bilateral orbital frontal cortex (OFC) and additional region in the left OFC extending to putamen and decreased in the primary visual, auditory, and motor cortices, right supplemental motor area, and bilateral thalami. There was a gradient in the extent of alterations such that SZ > BD > MDD. This cross-sectional study cannot consider medications and other clinical variables. These findings indicate a disrupted balance between network integration and segrega...Continue Reading
Citations
Aug 14, 2019·Cerebral Cortex·Ying WangJie Tian
Nov 23, 2019·Schizophrenia Bulletin·Qing MaMingrui Xia
Oct 4, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Linda A AntonucciNikolaos Koutsouleris
May 29, 2020·Brain and Behavior·Xin WenDezhong Yao
Jul 11, 2020·Psychological Medicine·Guanmao ChenYing Wang
Oct 6, 2019·Scientific Reports·Gerd WagnerFabrice Jollant
Jul 24, 2020·Translational Psychiatry·Yan-Ge WeiFei Wang
Jan 7, 2020·Schizophrenia Bulletin·Yuko NakamuraShinsuke Koike
Mar 17, 2020·Brain and Behavior·Chuanjun ZhuoCe Chen
Nov 3, 2020·Schizophrenia Bulletin·Xiaoyi SunMingrui Xia
Nov 20, 2020·Human Brain Mapping·Chao LiKe Xu
Dec 29, 2020·Frontiers in Neuroscience·Ruiqi FengFei Wang
Jan 16, 2021·American Journal of Psychotherapy·Kelsey A Bonfils, Danielle M Novick
Sep 16, 2019·Journal of Affective Disorders·Yue CuiTianzi Jiang
Feb 6, 2021·Translational Psychiatry·Gerd WagnerFabrice Jollant
Mar 24, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Du LeiMelissa P DelBello
May 15, 2021·PloS One·Kyungwon KimBoreom Lee
May 7, 2019·Journal of Affective Disorders·Alessio SimonettiKirti Saxena
Jul 5, 2021·World Neurosurgery·Tyler ScullenRobert F Dallapiazza
Aug 7, 2021·Brain Sciences·Marta PrietoAntonio Ibáñez-Molina
Aug 11, 2021·Schizophrenia Bulletin·Guorui ZhaoRuibin Zhang
Oct 15, 2021·Translational Psychiatry·Zhiyun YangKefeng Li
Sep 18, 2021·CNS & Neurological Disorders Drug Targets·Sevdalina KandilarovaKarsten Specht
Dec 21, 2021·Frontiers in Psychiatry·Chenyang YaoSu Lui