Local functional connectivity suggests functional immaturity in children with attention-deficit/hyperactivity disorder

Human Brain Mapping
Luis Marcos-VidalSusanna Carmona

Abstract

Previous studies have associated Attention-Deficit/Hyperactivity Disorder (ADHD) with a maturational lag of brain functional networks. Functional connectivity of the human brain changes from primarily local to more distant connectivity patterns during typical development. Under the maturational lag hypothesis, we expect children with ADHD to exhibit increased local connectivity and decreased distant connectivity compared with neurotypically developing (ND) children. We applied a graph-theory method to compute local and distant connectivity levels and cross-sectionally compared them in a sample of 120 children with ADHD and 120 age-matched ND children (age range = 7-17 years). In addition, we measured if potential group differences in local and distant connectivity were stable across the age range considered. Finally, we assessed the clinical relevance of observed group differences by correlating the connectivity levels and ADHD symptoms severity separately for each group. Children with ADHD exhibited more local connectivity than age-matched ND children in multiple brain regions, mainly overlapping with default mode, fronto-parietal and ventral attentional functional networks (p < .05- threshold free-cluster enhancement-family-w...Continue Reading

References

Feb 28, 1973·Annals of the New York Academy of Sciences·M Kinsbourne
Mar 1, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·B J CaseyJ L Rapoport
Aug 13, 1998·Journal of Abnormal Child Psychology·C K ConnersJ N Epstein
Oct 10, 2002·Biological Psychiatry·Stewart H MostofskyWalter E Kaufmann
Apr 21, 2007·Neuroscience and Biobehavioral Reviews·Edmund J S Sonuga-Barke, F Xavier Castellanos
Aug 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Damien A FairBradley L Schlaggar
Oct 30, 2007·Neuron·David C Van Essen, Donna L Dierker
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·P ShawJ L Rapoport
Dec 7, 2007·Brain & Development·Lixia TianYufeng Wang
Jan 15, 2008·Journal of Neuroscience Methods·Lucina Q UddinMichael P Milham
Oct 9, 2008·Neuroreport·Liberty S HamiltonKatherine L Narr
May 5, 2009·PLoS Computational Biology·Damien A FairSteven E Petersen
Jul 22, 2009·PLoS Biology·Kaustubh SupekarVinod Menon
Nov 6, 2009·Journal of Neurophysiology·Koene R A Van DijkRandy L Buckner
May 25, 2010·Human Brain Mapping·Philip ShawJudith Rapoport
Jun 16, 2010·PLoS Computational Biology·Jorge SepulcreRandy L Buckner
Sep 11, 2010·Science·Nico U F DosenbachBradley L Schlaggar
Jun 10, 2011·Journal of Neurophysiology·B T Thomas YeoRandy L Buckner
Aug 4, 2011·NeuroImage·Koene R A Van DijkRandy L Buckner
Sep 13, 2011·Trends in Cognitive Sciences·Vinod Menon
Dec 14, 2011·Biological Psychiatry·Dardo Tomasi, Nora D Volkow
Dec 16, 2011·Trends in Cognitive Sciences·F Xavier Castellanos, Erika Proal
Jul 27, 2012·Journal of Neurophysiology·Eun Young ChoiRandy L Buckner
Sep 18, 2012·The American Journal of Psychiatry·Samuele CorteseF Xavier Castellanos
Oct 11, 2012·PloS One·João Ricardo SatoLuis A Rohde
Jan 24, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Li AnYu-Feng Wang
Sep 3, 2013·NeuroImage·Jonathan D PowerSteven E Petersen
Sep 3, 2013·The Journal of Nervous and Mental Disease·Michael B First
Dec 18, 2013·Journal of the American Academy of Child and Adolescent Psychiatry·Susanna N VisserStephen J Blumberg
Mar 1, 2014·The Journal of Pediatrics·Lisa Marie LangevinDeborah Dewey
Mar 29, 2014·Human Brain Mapping·Chandra SripadaMichael Angstadt
Sep 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Chandra S SripadaMike Angstadt

❮ Previous
Next ❯

Citations

Jun 8, 2018·European Child & Adolescent Psychiatry·Maurizio BonatiUNKNOWN Lombardy ADHD Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.