PMID: 8960520Nov 1, 1996Paper

Local graft irradiation after failure of modern immunosuppression in acute cellular and vascular graft rejection

International Journal of Radiation Oncology, Biology, Physics
R JagetiaB B Mittal

Abstract

With improved chemical immunosuppressive agents, approximately 90% of rejection episodes can be reversed. However, in situations of failed immunosuppression, graft loss becomes inevitable. Our objective is to assess the efficacy of local graft irradiation (LGI) as an effort of last resort in a contemporary group of patients in whom graft failure to irreversible cellular and vascular rejection is imminent. A total of 308 renal transplantations were performed at our institution from 1992 to 1995, and an overall 1-year graft survival rate of 90% has been seen as a result of improvement in chemical immunosuppression. However, 6 patients were referred for LGI when all other measures failed to reverse the rejection crisis. Parameters that were studied in these patients included graft function and postirradiation graft histology. Irradiation was associated with reversal of the rejection crisis and resulted in documented histological long-term graft survival in 1 of the 6 patients (17%). Two of the six patients (33%) had reversal of the rejection episode based on postirradiation biopsy of the renal allograft. Three of the six patients showed some level of clinical improvement of graft function for varying periods of time. One patient m...Continue Reading

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Citations

Dec 16, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael DandelRoland Hetzer
Feb 6, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Nobuyuki ShibaSharon A Hunt
Jul 18, 2014·Nephro-urology Monthly·Mohammad Kazem FallahzadehNeeraj Singh
Dec 14, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Xavier StephenneEtienne M Sokal
Oct 8, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Rajesh RamanathanRobert A Fisher
Feb 3, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Joost J NuyttensAndrew T Turrisi
Mar 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Yuji SoejimaYoshihiko Maehara
Dec 7, 2006·American Journal of Clinical Oncology·Andrew O WahlMichael M Abecassis

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