Local heating of human skin causes hyperemia without mediation by muscarinic cholinergic receptors or prostanoids

Journal of Applied Physiology
Sandrine GolayF Feihl

Abstract

Local changes in surface temperature have a powerful influence on the perfusion of human skin. Heating increases local skin blood flow, but the mechanisms and mediators of this response (thermal hyperemia response) are incompletely elucidated. In the present study, we examined the possible dependence of the thermal hyperemia response on stimulation of muscarinic cholinergic receptors and on production of vasodilator prostanoids. In 13 male healthy subjects aged 20-30 yr, a temperature-controlled chamber was positioned on the volar face of one forearm and used to raise surface temperature from 34 to 41 degrees C. The time course of the resulting thermal hyperemia response was recorded with a laser-Doppler imager. In one experiment, each of eight subjects received an intravenous bolus of the antimuscarinic agent glycopyrrolate (4 microg/kg) on one visit and saline on the other. The thermal hyperemia response was determined within the hour after the injections. Glycopyrrolate effectively inhibited the skin vasodilation induced by iontophoresis of acetylcholine but did not influence the thermal hyperemia response. In a second experiment, conducted in five other subjects, 1 g of the cyclooxygenase inhibitor aspirin administered oral...Continue Reading

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Citations

Jun 5, 2010·Journal of Applied Physiology·John M Johnson, Dean L Kellogg
May 29, 2010·Journal of Applied Physiology·Christopher T Minson
Feb 25, 2006·Journal of Vascular Research·Kim M GoodingAngela C Shore
Aug 9, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Johanna FrantzFrançois Feihl
Jul 1, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Julien VionnetFrançois Feihl
Aug 1, 2006·Trends in Pharmacological Sciences·Jean-Luc CracowskiJohn R Halliwill
Mar 1, 2012·Microvascular Research·Sharad C AgarwalIan F Purcell
Jan 1, 2009·Dermatology Research and Practice·Pedro Contreiras Pinto, Luís Monteiro Rodrigues
Aug 25, 2006·The International Journal of Lower Extremity Wounds·M L IabichellaG Mosti
Dec 29, 2011·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Hidetoshi MoriKen Sasaki
Mar 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R J WidmerC M Quick
Feb 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gregg R McCordChristopher T Minson
Oct 22, 2005·Journal of Applied Physiology·Kichang Lee, Gary W Mack
Aug 16, 2018·Neurology. Genetics·Irène Calero-RomeroThierry Kuntzer
Mar 16, 2011·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Hidetoshi MoriHideo Ohsawa
Oct 1, 2005·Journal of Applied Physiology·Brett J WongChristopher T Minson
Apr 12, 2011·Experimental Physiology·Brett J Wong, Christopher T Minson
Jul 1, 2019··Wei Ru HanYang Ming Chou

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