PMID: 9422935Jan 10, 1998Paper

Local hypothermia protects the retina from ischaemic injury in vitrectomy

The British Journal of Ophthalmology
K TamaiA Majima

Abstract

Hypothermic irrigating solutions were used during vitrectomy in pressure induced ischaemic eyes so that their effects on retinal function and histological changes could be investigated. After anaesthetised albino rabbits underwent closed vitrectomy, their vitreous cavities were continuously irrigated for 30 minutes at a perfusion pressure of 140 mm Hg. The rabbits were divided into three groups according to their intraocular perfusion temperatures--8 degrees C, 22 degrees C, and 38 degrees C. Electroretinograms were taken before and after irrigation. Glutamate levels in the vitreous were examined after irrigation. Eyes were enucleated on the seventh postoperative day and examined histologically. On the seventh postoperative day, the recovery rate of a-wave amplitudes was significantly lower in the 38 degrees C group than in the 8 degrees C group, and that of b-wave amplitudes was significantly lower in the 38 degrees C group than in either the 8 degrees C or 22 degrees C group. Retinal damage in the 38 degrees C group revealed more severe histological impairment than in either the 8 degrees C or 22 degrees C group. Oedema of the inner retinal layer was significant in both the 22 degrees C and 38 degrees C groups. Glutamates rea...Continue Reading

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Citations

Aug 10, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jae Hui KimHyo Shin Ha
Oct 11, 2007·Japanese Journal of Ophthalmology·Takuya KataokaMasayoshi Iwaki
May 14, 2011·Japanese Journal of Ophthalmology·Masanori MizoteFumio Shiraga
Feb 10, 2004·Progress in Retinal and Eye Research·Neville N OsborneJosé Melena
Jul 23, 1999·Survey of Ophthalmology·N N OsborneM S Nash
Mar 8, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hiroshi KunikataKohji Nishida
Sep 16, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hsiao-Ming ChaoFang-Ping Chao
Nov 30, 2007·Retina·Morteza Mehdizadeh, Hossein Ashraf
Feb 24, 2006·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Hiroshi KunikataMakoto Tamai
Aug 8, 2014·International Ophthalmology·Guillermo Salcedo-VillanuevaMaurice B Landers
Aug 25, 2016·PloS One·Ignacio M LarrayozAlfredo Martínez
Jan 24, 2007·Life Sciences·Takashi KonnoNorimichi Nakahata
Jan 20, 2006·Current Eye Research·Atsuya MikiYasuo Tano
Jun 4, 2019·Clinical & Experimental Ophthalmology·Patricia KlemmSven Schnichels
Dec 21, 2019·Journal of Cataract and Refractive Surgery·Wenjuan WanKe Hu
Jul 18, 2020·Therapeutic Hypothermia and Temperature Management·Lukyan AnatychukOleg Zadorozhnyy
Aug 2, 2017·Scientific Reports·Manuel Rey-FunesAlfredo Martínez
Jan 1, 2021·Oxidative Medicine and Cellular Longevity·Lei Xi
Feb 7, 2006·Neuroscience Research·Min-Lin ChangChen-Yuan Wen

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